PE anti-mouse CD267 (TACI) Antibody
- 产品名称：
- PE anti-mouse CD267 (TACI) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 133403
- 产品应用：
- 133403
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Rat RBL transfected cell line
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per 106 cells in 100 ?l. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Siegel RM, et al. 2001. Nat. Immunol. 2:577.
- Von Bulow GU, et al. 1997. Science 278:138.
- Yan M, et al. 2001. Nat. Immunol. 2:638.
- Diaz-de-Durana Y, et al. 2006. Blood 107:594.
- Moir S, et al. 2012. Blood. 120:4850. PubMed.
- Product Citations
-
- Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed
- Pack AD, et al. 2021. Cell Reports. 36(8):109586. PubMed
- Zhu H, et al. 2019. Nat Commun. 10:1084. PubMed
- Werner A, et al. 2021. iScience. 24:103076. PubMed
- Moir S, et al. 2012. Blood. 120:4850. PubMed
- RRID
- AB_2203542 (BioLegend Cat. No. 133403) AB_2240584 (BioLegend Cat. No. 133404)
- Structure
- TACI/CD267 is a type III transmembrane protein belonging to TNF receptor superfamily (TNFSF). Among TNFSF members, TACI shares a high degree of homology with B cell maturation antigen (BCMA). It binds to the ligands BAFF (BLyS) and APRIL.
- Distribution
- CD267 is expressed predominantly by splenic transitional type 2 and marginal zone B cells, as well as activated B cells. But it is notably absent from germinal center B cells.
- Function
- CD267 appears to be particularly important for the regulation of B cell survival and maturation in the spleen. It is a major mediator of BAFF-dependent costimulatory responses in peripheral B cells. Signaling through TACI may serve to down-regulate B cell activity.
- Ligand/Receptor
- BAFF (Blys/TALL-1/THANK) and APRIL
- Cell Type
- B cells
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
-
1. Ng LG, et al. 2004. J. Immunology. 173:807.
- Gene ID
- 57916 View all products for this Gene ID
- UniProt
- View information about CD267 on UniProt.org
