Purified anti-mouse Aiolos Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1692	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

N-terminal half of mouse Aiolos fused to GST

Formulation

This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.

Concentration

0.5 mg/mL

Storage & Handling

Upon receipt, store undiluted between 2°C and 8°C.

Application

WB - Quality tested
ICFC, IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5 ?g/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: intracellular flow cytometry¹, immunoprecipitation¹, and Western blotting².

Does not cross-react with human.

View more applications data for a different format of this clone in our Scientific Poster Library.

This product is for research use only, cannot be used on or in humans, and is not to be used for commercial purposes.? Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited.? In order to obtain a license to use this product for commercial purposes, contact the Regents of the University of California.

Application References (PubMed link indicates BioLegend citation)

Laszlo G, et al. 1993. J. Immunol. 150:5252. (ICFC, IP)
Thompson EC, et al. 2007. Immunity 26:335. (WB)

Product Citations

Wei SC, et al. 2019. Immunity. 50:1084. PubMed

RRID

AB_2561708 (BioLegend Cat. No. 653201) AB_2561709 (BioLegend Cat. No. 653202)

Antigen Details

Structure: 509 amino acids with predicted MW of 58 kD
Distribution: Nucleus, cytoplasm
Restricted to lymphoid lineage, expressed in B, NK and T cells
Function: Transcription factor that plays an important role in the regulation of lymphocyte differentiation; plays an essential role in regulation of B-cell differentiation, proliferation, and maturation to an effector state
Interaction: Homodimer and heterodimer with other IKAROS family members; interacts with IKZF4, IKZF5, IKZF1, HRAS, FOXP3, and BCL21L isoform Bcl-X(L); associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A
Cell Type: B cells, NK cells, T cells
Biology Area: Cell Biology, Chromatin Remodeling/Epigenetics, Immunology, Innate Immunity, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Morgan B, et al. 1997. EMBO J. 16:2004.
2. Wang JH, et al. 1998. Immunity 9:543.
3. Cariappa A, et al. 2001. Immunity 14:603.
Gene ID: 22780 View all products for this Gene ID
UniProt: View information about Aiolos on UniProt.org

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