Alexa Fluor® 647 anti-mouse Aiolos Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1908	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

N-terminal half of mouse Aiolos fused to GST

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 647 under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

ICFC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis.?For flow cytometric staining, the suggested use of this reagent is ≤0.125 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor? 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.

Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

View full statement regarding label licenses

Excitation Laser

Red Laser (633 nm)

Application Notes

Additional reported applications (for the relevant formats) include: intracellular flow cytometry¹, immunoprecipitation¹, and Western blotting².

Does not cross-react with human.

View more applications data for a different format of this clone in our Scientific Poster Library.

This product is for research use only, cannot be used on or in humans, and is not to be used for commercial purposes.? Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited.? In order to obtain a license to use this product for commercial purposes, contact the Regents of the University of California.

Application References (PubMed link indicates BioLegend citation)

Laszlo G, et al. 1993. J. Immunol. 150:5252. (ICFC, IP)
Thompson EC, et al. 2007. Immunity 26:335. (WB)

RRID

AB_2563238 (BioLegend Cat. No. 653205) AB_2563239 (BioLegend Cat. No. 653206)

Antigen Details

Structure: 509 amino acids with predicted MW of 58 kD
Distribution: Nucleus, cytoplasm
Restricted to lymphoid lineage, expressed in B, NK and T cells
Function: Transcription factor that plays an important role in the regulation of lymphocyte differentiation; plays an essential role in regulation of B-cell differentiation, proliferation, and maturation to an effector state
Interaction: Homodimer and heterodimer with other IKAROS family members; interacts with IKZF4, IKZF5, IKZF1, HRAS, FOXP3, and BCL21L isoform Bcl-X(L); associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A
Cell Type: B cells, NK cells, T cells
Biology Area: Cell Biology, Chromatin Remodeling/Epigenetics, Immunology, Innate Immunity, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Morgan B, et al. 1997. EMBO J. 16:2004.
2. Wang JH, et al. 1998. Immunity 9:543.
3. Cariappa A, et al. 2001. Immunity 14:603.
Gene ID: 22780 View all products for this Gene ID
UniProt: View information about Aiolos on UniProt.org

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