Purified anti-human HLA-G Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 1416	1

Product Details

Verified Reactivity

Human

Reported Reactivity

African Green, Cynomolgus, Rhesus

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

HLA-G transfected cells

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
ELISA, IHC-F - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 10⁶ cells in 100 ?l volume or 100 ?l of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

87G mAb reacts with isoforms of HLA-G1 and -G5. Additional reported applications (for the relevant formats) include: restoring HLA-G mediated suppression of allo-T cell proliferation and immunohistochemical staining of frozen tissue sections. Clone 87G is reported not to bind HLA-G in aldehyde fixed samples.⁴

Application References (PubMed link indicates BioLegend citation)

Odum N, et al. 1991. Eur. J. Immunol. 21:2121.
Lila N, et al. 2001. P. Natl. Acad. Sci. USA 98:12150.
Lila N, et al. 2002. Circulation. 105:1949.
Blaschitz A, et al. 2000. Hum. Immunol. 61:1074.
Balsamo M, et al. 2012. Eur J. Immunol. 42:1833. PubMed

Product Citations

Wurzer H, et al. 2021. Front Immunol. 12:619069. PubMed
Balsamo M, et al. 2012. Eur J Immunol. 42:1833. PubMed

RRID

AB_1227707 (BioLegend Cat. No. 335902)

Antigen Details

Structure: Ig
Distribution: Trophoblast cells, thymic epithelial cells, cytokine-activated moncytes, macrophages/dendritic cells during viral infection, various tumors
Function: Inhibit NK and T cell-mediated cytolysis and T cell proliferation, induce apoptosis of activated CD8⁺ T cells, induce Th2 cytokine production
Ligand/Receptor: ILT2(CD85j), ILT4(CD85d), KIR2DL4(CD158d), CD8α/α
Cell Type: Dendritic cells, Epithelial cells, Macrophages, Monocytes
Biology Area: Immunology
Molecular Family: MHC Antigens
Antigen References: 1. Hunt JS, et al. 2005. FASEB J. 19:681.
2. Carosella ED, et al. 2008. Blood 111:4862.
Gene ID: 3135 View all products for this Gene ID
UniProt: View information about HLA-G on UniProt.org

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