PE anti-mouse CD370 (CLEC9A, DNGR1) Antibody
- 产品名称：
- PE anti-mouse CD370 (CLEC9A, DNGR1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 143503
- 产品应用：
- 143503
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume.? It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: ELISA2, immunofluorescence microcopy1, immunoprecipitation1, and Western blotting1.
- Application References
(PubMed link indicates BioLegend citation) -
- Sancho D, et al. 2008. J. Clin. Invest. 118:2098. (IF, IP, WB)
- Joffre OP, et al. 2010. Eur. J. Immunol. 40:1255. (ELISA)
- Product Citations
-
- Findlay EG, et al. 2019. Oncoimmunology. 8:1608106. PubMed
- Chopin M et al. 2018. Immunity. 50(1):77-90 . PubMed
- Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed
- Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
- Fusciello M, et al. 2019. Nat Commun. 4.407638889. PubMed
- RRID
- AB_11147366 (BioLegend Cat. No. 143503) AB_11147953 (BioLegend Cat. No. 143504)
- Structure
- Type II transmembrane glycoprotein, consists of a 35 amino acid (aa) cytoplasmic domain with an ITAM-like motif, a 21 aa transmembrane segment, and a 185 extracellular domain (ECD) that contains a stalk region and one C-type lectin domain (CTLD)
- Distribution
-
Strictly expressed on CD8α+ dendritic cells, migratory CD103+ dendritic cells, and plasmacytoid dendritic cells
- Function
- Cross present antigen to CTL
- Interaction
- Necrotic cells
- Ligand/Receptor
- Ubiquitous preformed acid-labile protein associated ligand(s)
- Cell Type
- Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, MHC Antigens
- Antigen References
-
Poulin LF, et al. 2012. Blood 119:6052.
- Gene ID
- 232414 View all products for this Gene ID
- UniProt
- View information about CD370 on UniProt.org
