Biotin anti-mouse CD278 (ICOS) Antibody
- 产品名称：
- Biotin anti-mouse CD278 (ICOS) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 117403
- 产品应用：
- 117403
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse ICOS cDNA and ICOS hexahistidine fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is = 0.25 ?g per 106 cells in 100 ?l volume.
- Application Notes
Additional reported applications (for the relevant formats) include: blocking of ligand binding. The LEAF? format is suggested for blocking studies.
- Application References
(PubMed link indicates BioLegend citation) -
- Akbari O, et al. 2002. Nat. Med. 8:1024.
- Harada H, et al. 2003. J. Clin. Invest. 112:234.
- McAdam AJ, et al. 2000. J. Immunol. 165:5035. (FC Block)
- Tan SL, et al. 2006. J. Immunol. 176:2872. PubMed
- Product Citations
-
- Cook KD, et al. 2015. Immunity. 43:703-714. PubMed
- Miyauchi K, et al. 2016. Nat Immunol. 17:1447-1458. PubMed
- Cortes JR et al. 2018. Cancer cell. 33(2):259-273 . PubMed
- RRID
- AB_961239 (BioLegend Cat. No. 117403)
- Structure
- CD28/CTLA-4, 47-57kD
- Distribution
-
Activated T cells, subset of thymocytes
- Function
- Costimulates T cell activation, proliferation, humoral immune response
- Ligand/Receptor
- B7h/B7RP-1/GL-50
- Cell Type
- T cells, Thymocytes
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Rudd CE, et al. 2003. Nat. Rev. Immunol. 3:544.
2. McAdam AJ, et al. 2000. J. Immunol. 165:5035.
3. Mak TW, et al. 2003. Nat. Immunol. 4:765
- Gene ID
- 54167 View all products for this Gene ID
- UniProt
- View information about CD278 on UniProt.org
