FITC anti-human/mouse Bcl-6 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1764	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

Sequence 226-398 of murine BCL6 fused with GST

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC -?Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume or 5 ?L per 100 ?L of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser

Blue Laser (488 nm)

Application Notes

Additional reported applications (for the relevant formats) include: Western blotting^1,2,3.

Application References (PubMed link indicates BioLegend citation)

Vikstrom, et al. 2010. Science 330:1095. (WB)
Kallies A, et al. 2011. Blood 117:1869. (WB)
Lüthje K, et al. 2012. Nat. Immunol. 13:491. (WB)
Tonti E, et al. 2012. J. Immunol. 188:3217. (ICFC)

Product Citations

Kramer KJ, et al. 2022. Nat Commun. 13:3466. PubMed
Seydoux E, et al. 2021. Cell Reports. 35(5):109084. PubMed

RRID

AB_2860942 (BioLegend Cat. No. 358513) AB_2860943 (BioLegend Cat. No. 358514)

Antigen Details

Structure: Member of the BTB-POZ zinc finger family, 80 kD, homodimer, 1 BTB (POZ) domain, 6 C2H2-type zinc fingers
Distribution: Germinal center B cells, follicular helper T cells (T_FH), B cell lymphomas, breast cancer cells
Function: Transcription factor, master regulator of germinal center reaction
Interaction: BLIMP-1
Cell Type: B cells, Tfh
Biology Area: Cell Biology, Immunology, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Basso K and Dalla-Favera R. 2012. Immunol. Rev. 247:172.
2. Vinuesa CG, and Cyster JG, 2011. Immunity 35:671.
3. Kitano M, et al. 2011. Immunity 34:961.
4. Baumjohann D,?et al. 2011. J. Immunol. 187:2089.
5. Johnston RJ, et al. 2009. Science. 325:1006.
6. Tran TH, et al. 2010. Cancer Res. 70:1711.
Gene ID: 604 View all products for this Gene ID
UniProt: View information about Bcl-6 on UniProt.org

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