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APC anti-human/mouse Bcl-6 Antibody
产品名称：
APC anti-human/mouse Bcl-6 Antibody
产品类别：
抗体
产品编号：
358505
产品应用：
358505
[价格]
规格 价格 库存
25tests ￥ 1788 1

产品详情

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Sequence 226-398 of murine BCL6 fused with GST
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining using our nuclear factor staining protocol. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: Western blotting1,2,3.

Application References

(PubMed link indicates BioLegend citation)
  1. Vikstrom, et al. 2010. Science 330:1095. (WB)
  2. Kallies A, et al. 2011. Blood 117:1869. (WB)
  3. Lüthje K, et al. 2012. Nat. Immunol. 13:491. (WB)
  4. Tonti E, et al. 2012. J. Immunol. 188:3217. (ICFC)
Product Citations
  1. Delacher M, et al. 2021. Immunity. 54(4):702-720.e17. PubMed
  2. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
  3. Zeng W, et al. 2016. Sci Rep. 6:36560. PubMed
  4. Firmino NS, et al. 2021. Oncoimmunology. 10:1959978. PubMed
  5. Haniuda K, et al. 2020. Cell Rep. 33:108333. PubMed
  6. Fu Y, et al. 2021. Cell Reports. 36(2):109344. PubMed
  7. Su C, et al. 2020. Nat Commun. 2.745833333. PubMed
  8. Mansouri S, et al. 2021. J Immunol. 206:2233. PubMed
RRID
AB_2562471 (BioLegend Cat. No. 358505) AB_2562472 (BioLegend Cat. No. 358506)

Antigen Details

Structure
Member of the BTB-POZ zinc finger family, 80 kD, homodimer, 1 BTB (POZ) domain, 6 C2H2-type zinc fingers
Distribution

Germinal center B cells, follicular helper T cells (TFH), B cell lymphomas, breast cancer cells

Function
Transcription factor, master regulator of germinal center reaction
Interaction
BLIMP-1
Cell Type
B cells, Tfh
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family
Nuclear Markers
Antigen References

1. Basso K and Dalla-Favera R. 2012. Immunol. Rev. 247:172.
2. Vinuesa CG, and Cyster JG, 2011. Immunity 35:671.
3. Kitano M, et al. 2011. Immunity 34:961.
4. Baumjohann D,?et al. 2011. J. Immunol. 187:2089.
5. Johnston RJ, et al. 2009. Science. 325:1006.
6. Tran TH, et al. 2010. Cancer Res. 70:1711.

Gene ID
604 View all products for this Gene ID
UniProt
View information about Bcl-6 on UniProt.org

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