APC anti-human Siglec-8 Antibody
- 产品名称：
- APC anti-human Siglec-8 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 347105
- 产品应用：
- 347105
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1848 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Siglec-8 fused to human IgG Fc
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Floyd H, et al. 2000. J. Biol. Chem. 275:861.
- Wen T, et al. 2014. J Immunol. 192:5481. PubMed
- Product Citations
-
- Toepfner N et al. 2018. eLife. 7 pii: e29213. PubMed
- Patra V, et al. 2019. Br J Dermatol. N/A. PubMed
- Kim JE, et al. 2021. Front Immunol. 11:593748. PubMed
- Gravastrand CS, et al. 2019. J Immunol. 203(4). PubMed
- Simon SCS, et al. 2020. Oncoimmunology. 9:1727116. PubMed
- Morshed N, et al. 2020. Mol Syst Biol. 16:e9819. PubMed
- Golebski K, et al. 2021. Immunity. 54(2):291-307.e7. PubMed
- Zhu YP et al. 2018. Cell reports. 24(9):2329-2341 . PubMed
- Ehrens A, et al. 2021. Cell Reports. 34(2):108621. PubMed
- Plum T, et al. 2020. Immunity. 52(2):404-416. PubMed
- RRID
- AB_2561401 (BioLegend Cat. No. 347105) AB_2561402 (BioLegend Cat. No. 347106)
- Structure
- A lectin of 54 kD, belonging to the Ig-superfamily; has one V-set Ig-like domain and two C2-set domains; has a single transmembrane domain, and two immunoreceptor tyrosine-based inhibitor motifs (ITIM) in the cytoplasmic domain
- Distribution
-
Eosinophils, basophils, mast cells
- Function
- Cell adhesion, signal transduction
- Interaction
- Phosphatases containing a SH2 domain
- Bioactivity
- Inhibition of IgE receptor-triggered histamine and prostaglandin D2 release, apoptosis
- Cell Type
- Basophils, Eosinophils, Mast cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- Adhesion Molecules, Siglec Molecules
- Antigen References
-
1. Bochner BS, et al. 2009. Clin. Exp. Allergy. 39:317.
2. Hudson SA, et al. 2009. J. Pharmacol. Exp. Ther. 330:608.
3. Nutku E, et al. 2005. Biochem. Biophys. Res. Commun. 336:918.
- Gene ID
- 27181 View all products for this Gene ID
- UniProt
- View information about Siglec-8 on UniProt.org
