PE anti-human CD169 (Sialoadhesin, Siglec-1) Antib
- 产品名称：
- PE anti-human CD169 (Sialoadhesin, Siglec-1) Antib
- 产品类别：
- 抗体
- 产品编号：
- 346003
- 产品应用：
- 346003
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1548 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Rhinovirus (HRV14) infected, monocyte derived-DCs
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: Western blotting and inhibition of erythrocyte-rosetting with cells expressing CD169.
- Application References
(PubMed link indicates BioLegend citation) -
- Kirchberger S, et al. 2005. J. Immunol. 175:1145.
- Schrauf C, et al. 2009. J. Immunol. 183:4440.
- Product Citations
-
- Silvin A, et al. 2020. Cell. 182:1401. PubMed
- van der Wijst MGP, et al. 2021. Sci Transl Med. 13:eabh2624. PubMed
- Ostendorf L, et al. 2021. Scientific Reports. 11(1):10299. PubMed
- OhAinle M et al. 2018. eLife. 7 pii: e39823. PubMed
- Heikema A, et al. 2013. Infect Immun . 81:2095. PubMed
- Saito Y, et al. 2015. Cancer Immunol Res. 3: 1356 - 1363. PubMed
- Perez–Zsolt D, et al. 2019. Front Immunol. 0.989583333. PubMed
- Cassetta L et al. 2019. Cancer Cell. 35(4):588-602 . PubMed
- Okoye AA, et al. 2018. Nat Med. 24:1430. PubMed
- Leylek R, et al. 2019. Cell Rep. 29:3736. PubMed
- Kim WK, et al. 2015. AIDS Res Hum Retroviruses . 31: 696-706. PubMed
- Benet S, et al. 2021. J Extracell Vesicles. 10:e12046. PubMed
- RRID
- AB_2189030 (BioLegend Cat. No. 346003) AB_2189029 (BioLegend Cat. No. 346004)
- Structure
- Type I single membrane-spanning lectin, 1709 amino acids, 210 kD, belongs to the immunoglobulin superfamily
- Distribution
-
Macrophages, dendritic cells
- Function
- Adhesion molecule
- Interaction
- α-2,3-linked sialic acid
- Ligand/Receptor
- CD227, CD43 and CD206
- Bioactivity
- Mediates sialic-acid dependent binding to granulocytes, monocytes, NK, B and T cells.
- Cell Type
- B cells, Dendritic cells, Macrophages
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Adhesion Molecules, CD Molecules, Siglec Molecules
- Antigen References
-
1. Xiong YS, et al. 2009. Clin. Biochem. 42:1057.
2. Varki A, et al. 2009. Glycoconj J. 26:231.
3. Rempel H, et al. 2008. PLoS One. 3:e1967.
4. Crocker PR, et al. 2001. Trends Immunol. 22:337.
5. Hartnell A, et al. 2001. Blood 97:288.
- Gene ID
- 6614 View all products for this Gene ID
- UniProt
- View information about CD169 on UniProt.org
