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Purified anti-CaMKII Antibody
产品名称：
Purified anti-CaMKII Antibody
产品类别：
抗体
产品编号：
688602
产品应用：
688602
[价格]
规格 价格 库存
100µg ￥ 4080 1

产品详情

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
50% pure type II CaM kinase, purified through Calmodulin-Sepharose step.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
IHC-F - Verified
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g/ml. For immunohistochemical staining on frozen tisse sections, a concentration range of 2.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Erondu NE, et al. 1985. J. Neurosci. 5:3270.
RRID
AB_2617027 (BioLegend Cat. No. 688602)

Antigen Details

Structure
478 amino acids with a predicted molecular weight of 50 kD.
Distribution

Synapse and cytosol.

Function
A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release; member of the NMDAR signaling complex in excitatory synapses it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
Interaction
BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.
Biology Area
Cell Biology, Immunology, Signal Transduction
Molecular Family
Protein Kinases/Phosphatase, TCRs
Antigen References

1. Hook SS, et al. 2001. Annu. Rev. Pharmacol. Toxicol. 41:471.
2. Hoelz A, et al. 2003. Mol. Cell 11:1241.
3. Lisman J, et al. 2012. Nat. Rev. Neurosci. 13:169.
4. Barria A, et al. 1997. Science 276:2042.
5. Hughes K, et al. 2001. J. Biol. Chem. 276:36008.
6. Wang YY, et al. 2015. Oncotarget. 6:11725.

Gene ID
815 View all products for this Gene ID
UniProt
View information about CaMKII on UniProt.org

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