Purified anti-Histone H4 Trimethyl (Lys 20) Antibo
- 产品名称：
- Purified anti-Histone H4 Trimethyl (Lys 20) Antibo
- 产品类别：
- 抗体
- 产品编号：
- 827701
- 产品应用：
- 827701
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This monoclonal antibody was raised against a synthetic peptide conjugated to KLH containing trimethylated lysine 20 of human Histone H4
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Application
-
IHC-P -?Quality tested
WB -?Verified
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2.0 - 10 ?g/mL is suggested. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 ?g/mL.?It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Botuyan MV, et al. 2006. Cell. 127:1361. (WB)
- Product Citations
-
- Wimmers F, et al. 2021. Cell. 184:3915. PubMed
- RRID
- AB_2564914 (BioLegend Cat. No. 827701)
- Structure
- Histone proteins H3 and H4 bind to form a tetramer. This tetramer further combines with two H2a-H2b dimers to form the compact Histone octamer core.
- Distribution
-
Histone H4 is ubiquitously expressed in all cells.
- Function
- Transcription regulation, DNA repair, DNA replication, chromosomal stability, silencing of repetitive DNA and transposons.
- Interaction
- Various transcription factors.
- Biology Area
- Cancer Biomarkers, Cell Biology, Chromatin Remodeling/Epigenetics, Neuroscience, Transcription Factors
- Antigen References
-
1. Chen HM, et al. 2015. Epigenetics and Dermatology 409.
2. Bhasin M,?et al. 2006. J. Comput. Biol. 13:102.
3. Nelson DM, et al. 2016. Genome Biol. 17:158.?
- Gene ID
- 8359 View all products for this Gene ID
- UniProt
- View information about Histone H4 Trimethyl on UniProt.org
