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抗体蛋白

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首页 > 抗体蛋白 > 抗体
Purified anti-β-Amyloid, 1-16 Antibody (Prev
产品名称：
Purified anti-β-Amyloid, 1-16 Antibody (Prev
产品类别：
抗体
产品编号：
803004
产品应用：
803004
[价格]
规格 价格 库存
25µL ￥ 1344 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution (no preservatives or carrier proteins).
Preparation
The antibody was purified by affinity chromatography.
Concentration
1 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

WB -?Quality tested
Direct ELISA, IHC-P?-?Verified
IHC-F, EM, ICC -??Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1 ?g/mL. For Direct ELISA, the suggested use of this reagent is 0.002 - 0.02 ?g/mL.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is?0.2 - 5.0 ?g/mL. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS).

This antibody clone has been reported for use in immunohistochemistry of free-floating sections2,13.

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Application References

(PubMed link indicates BioLegend citation)
  1. Thakker DR,?et al. 2009.?Proc. Natl. Acad. Sci. USA.?106(11):4501-6.?(IHC)?PubMed
  2. Oddo S,?et al. 2005.?Proc. Natl. Acad. Sci. USA.?102(8):3046-51.?(IHC-other)?PubMed
  3. Herzig M,?et al. 2004.?Nat. Neuro.?7(9):954-959.?(WB)?PubMed
  4. Zheng Y,?et al.?2012.?PLoS One?6:39035.?(IHC-F)?PubMed
  5. Abramowksi D,?et al.?J Neurosci.?32:1273.?(WB)?PubMed
  6. Forny-Germano L,?et al.?2014.?J. Neurosci.?34:13629.?(WB, IHC)?PubMed
  7. Gowert NS,?et al.?2014.?PLoS One?2:e90523.?(ICC, EM)?PubMed
  8. Sandoval-Hernández A,?et al.?2015.?PLoS One. 10: 0145467.?(IHC-F)
  9. Kumar R,?et al.?2016.?Brain.?139:174-92?(WB)
  10. Miyamoto T,?et al.?2016. J. Biol. Chem. 291:1719-34.?(WB)
  11. Saito S,?et al.?2017.?Acta Neuropathol. Commun.?5:26-9.?(IHC-P)?PubMed
  12. Omata Y,?et al.?2016.?Aging (Albany NY)?8(3):427.?(IHC-P)?PubMed
  13. Peng W,?et al.?2016.?Neurobiol. Dis.?93:215.?(IHC-other)?PubMed
  14. Mandler M,?et al.?2015.?PLoS One.?e0115237.?(WB, IHC, ELISA)?PubMed
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RRID
AB_2715854 (BioLegend Cat. No. 803004) AB_2564653 (BioLegend Cat. No. 803001) AB_2564654 (BioLegend Cat. No. 803002) AB_2564652 (BioLegend Cat. No. 803003)

Antigen Details

Structure
Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.
Distribution

Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle.
Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus.

Function
The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
APP/β-Amyloid
Antigen References
  1. Kumar A,?et al.?2015. Pharmacol. Rep. 67(2):195.
  2. Sadigh-Eteghad S,?et al. 2015. Med. Princ. Pract. 24(1):1
  3. Hampel H,?et al.?2015.?Expert Rev. Neurother.?15(1):83.
  4. Puig KL,?et al.?2012. ?Exp. Gerontol. 48(7): 608.
  5. Selkoe DJ,?et al.?2016.?EMBO Mol. Med.?8(6):595.
  6. Walsh DM,?et al.??2007.?J. Neurochem. 101(5):1172.
Gene ID
351 View all products for this Gene ID
UniProt
View information about beta-Amyloid, 1-16 on UniProt.org

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