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Biotin anti-β-Amyloid, 1-16 Antibody (Previo
产品名称：
Biotin anti-β-Amyloid, 1-16 Antibody (Previo
产品类别：
抗体
产品编号：
803007
产品应用：
803007
[价格]
规格 价格 库存
200µL ￥ 7848 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution; no preservatives or carrier proteins.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

IHC-P - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS).

This antibody clone has been reported for use in immunohistochemistry of free-floating sections2,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Thakker DR,?et al. 2009.?Proc. Natl. Acad. Sci. USA.?106(11):4501-6.?(IHC)?PubMed
  2. Oddo S,?et al. 2005.?Proc. Natl. Acad. Sci. USA.?102(8):3046-51.?(IHC-other)?PubMed
  3. Herzig M,?et al. 2004.?Nat. Neuro.?7(9):954-959.?(WB)?PubMed
  4. Zheng Y,?et al.?2012.?PLoS One?6:39035.?(IHC-F)?PubMed
  5. Abramowksi D,?et al.?J Neurosci.?32:1273.?(WB)?PubMed
  6. Forny-Germano L,?et al.?2014.?J. Neurosci.?34:13629.?(WB, IHC)?PubMed
  7. Gowert NS,?et al.?2014.?PLoS One?2:e90523.?(ICC, EM)?PubMed
  8. Sandoval-Hernández A,?et al.?2015.?PLoS One. 10: 0145467.?(IHC-F)
  9. Kumar R,?et al.?2016.?Brain.?139:174-92?(WB)
  10. Miyamoto T,?et al.?2016. J. Biol. Chem. 291:1719-34.?(WB)
  11. Saito S,?et al.?2017.?Acta Neuropathol. Commun.?5:26-9.?(IHC-P)?PubMed
  12. Omata Y,?et al.?2016.?Aging (Albany NY)?8(3):427.?(IHC-P)?PubMed
  13. Peng W,?et al.?2016.?Neurobiol. Dis.?93:215.?(IHC-other)?PubMed
  14. Mandler M,?et al.?2015.?PLoS One.?e0115237.?(WB, IHC, ELISA)?PubMed
Product Citations
  1. Alfonso S, et al. 2016. Sci Signal. 9: ra47. PubMed
  2. Sompol P, et al. 2021. Aging Cell. :e13416. PubMed
  3. Mateus A, et al. 2017. Proc Natl Acad Sci U S A. 114:E6231. PubMed
  4. Chen JF, et al. 2021. Neuron. . PubMed
  5. Larson M, et al. 2012. J Neurosci. 32:10253-10266. PubMed
  6. Chiang ACA, et al. 2018. Am J Pathol. 188:739. PubMed
  7. Sompol P et al. 2017. The Journal of Neuroscience. 37(25):6132-6148 . PubMed
  8. Osborne C, et al. 2018. J Cell Sci. 131:. PubMed
  9. Sherman M, et al. 2016. J Neurosci. 36: 9647 - 9658. PubMed
  10. Zhou Z, et al. 2017. J Neuroinflammation. 14:75. PubMed
  11. Fitz NF, et al. 2020. Mol Neurodegener. 15:41. PubMed
  12. Grant MKO, et al. 2019. PLoS One. 14:e0212815. PubMed
  13. Chernick D, et al. 2018. J Neurochem. 147:647. PubMed
  14. Duncan MJ, et al. 2019. Alzheimers Dement (N Y). 5:70. PubMed
  15. Carter A, et al. 2017. PLoS One. 12(2):e0172161. PubMed
  16. Lathuilière A, et al. 2016. Brain. 10.1093/brain/aww036. PubMed
  17. Thygesen C, et al. 2018. Front Cell Neurosci. 12:397. PubMed
  18. West E, et al. 2017. J Cell Sci. 130:3050. PubMed
  19. Metaxas A, et al. 2019. Front Cell Neurosci. 0.915277778. PubMed
RRID
AB_2564657 (BioLegend Cat. No. 803007) AB_2564658 (BioLegend Cat. No. 803008) AB_2564656 (BioLegend Cat. No. 803009)

Antigen Details

Structure
Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.
Distribution

Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle.
Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus.

Function
The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
APP/β-Amyloid
Antigen References
  1. Kumar A,?et al.?2015. Pharmacol. Rep. 67(2):195.
  2. Sadigh-Eteghad S,?et al. 2015. Med. Princ. Pract. 24(1):1
  3. Hampel H,?et al.?2015.?Expert Rev. Neurother.?15(1):83.
  4. Puig KL,?et al.?2012. ?Exp. Gerontol. 48(7): 608.
  5. Selkoe DJ,?et al.?2016.?EMBO Mol. Med.?8(6):595.
  6. Walsh DM,?et al.??2007.?J. Neurochem. 101(5):1172.
Gene ID
351 View all products for this Gene ID
UniProt
View information about beta-Amyloid, 1-16 on UniProt.org

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