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首页 > 抗体蛋白 > 抗体
Anti-β-Amyloid, 1-16 Antibody (Previously Cov
产品名称：
Anti-β-Amyloid, 1-16 Antibody (Previously Cov
产品类别：
抗体
产品编号：
803014
产品应用：
803014
[价格]
规格 价格 库存
50µL ￥ 3600 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Preparation
Ascites
Concentration
The concentration is not quantified as this product is sold as undiluted crude mouse ascites fluid. The concentration might vary from lot-to-lot and an estimated concentration would be 1-3 mg/ml.
Storage & Handling
Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers.
Application

WB -?Quality tested
Direct ELISA, IHC-P -?Verified
IHC-F, EM -?Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested dilution of this reagent is 1:1,000 to 1:20,000. For Direct ELISA, the suggested dilution of this reagent is 1:10,000 to 1:100,000.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, the suggested dilution of this reagent is?1:1,000 to 1:20,000. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS).

This antibody clone has been reported for use in immunohistochemistry of free-floating sections2,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Thakker DR,?et al. 2009.?Proc. Natl. Acad. Sci. USA.?106(11):4501-6.?(IHC)?PubMed
  2. Oddo S,?et al. 2005.?Proc. Natl. Acad. Sci. USA.?102(8):3046-51.?(IHC-other)?PubMed
  3. Herzig M,?et al. 2004.?Nat. Neuro.?7(9):954-959.?(WB)?PubMed
  4. Zheng Y,?et al.?2012.?PLoS One?6:39035.?(IHC-F)?PubMed
  5. Abramowksi D,?et al.?J Neurosci.?32:1273.?(WB)?PubMed
  6. Forny-Germano L,?et al.?2014.?J. Neurosci.?34:13629.?(WB, IHC)?PubMed
  7. Gowert NS,?et al.?2014.?PLoS One?2:e90523.?(ICC, EM)?PubMed
  8. Sandoval-Hernández A,?et al.?2015.?PLoS One. 10: 0145467.?(IHC-F)
  9. Kumar R,?et al.?2016.?Brain.?139:174-92?(WB)
  10. Miyamoto T,?et al.?2016. J. Biol. Chem. 291:1719-34.?(WB)
  11. Saito S,?et al.?2017.?Acta Neuropathol. Commun.?5:26-9.?(IHC-P)?PubMed
  12. Omata Y,?et al.?2016.?Aging (Albany NY)?8(3):427.?(IHC-P)?PubMed
  13. Peng W,?et al.?2016.?Neurobiol. Dis.?93:215.?(IHC-other)?PubMed
  14. Mandler M,?et al.?2015.?PLoS One.?e0115237.?(WB, IHC, ELISA)?PubMed
Product Citations
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  6. Lai RH, et al. 2021. Aging Cell. 20:e13509. PubMed
  7. Arber C, et al. 2019. Brain Commun. 1:fcz024. PubMed
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  11. Beraldo F, et al. 2016. J Biol Chem. 291: 21945 - 21955. PubMed
  12. Mukherjee J, et al. 2021. Synapse. 75:e22183. PubMed
  13. Zhang H, et al. 2016. J Neurosci. 36: 11837 - 11850. PubMed
  14. Robert J et al. 2017. eLife. 6 pii: e29595. PubMed
  15. Na H, et al. 2021. Am J Alzheimers Dis Other Demen. 36:15333175211012867. PubMed
  16. Shen Q, et al. 2022. Aging Cell. 21:e13573. PubMed
  17. Zheng Y, et al. 2012. PLoS One. 7:e39035. PubMed
  18. Soto-Mercado V, et al. 2020. J Alzheimers Dis. . PubMed
  19. Shen Y, et al. 2020. Theranostics. 10:11794. PubMed
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  21. Nguyen GAH, et al. 2022. Molecules. 27:. PubMed
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  23. Suh J, et al. 2020. Cell. 178(5):1159-1175.e17.. PubMed
  24. Soto-Mercado V, et al. 2021. Biomolecules. 11:. PubMed
  25. Lyra E Silva NM, et al. 2021. Transl Psychiatry. 251:11. PubMed
  26. Benthem SD, et al. 2020. Current Biology. 30(13):2588-2601.e5. PubMed
  27. Cheng WH, et al. 2019. Alzheimers Res Ther. 11:6. PubMed
  28. Zhang J, et al. 2021. Aging Cell. 20:e13380. PubMed
  29. Moelgg K, et al. 2021. Biomolecules. 11:. PubMed
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  32. Kaur H, et al. 2021. Bioorg Med Chem Lett. 46:128164. PubMed
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  34. Kumar S, et al. 2022. NPJ Genom Med. 7:47. PubMed
  35. Casali BT, et al. 2020. Neurobiol Dis. 142:104956. PubMed
  36. Quartey MO, et al. 2021. Sci Rep. 0.757638889. PubMed
  37. Klohs J, et al. 2016. J Cereb Blood Flow Metab. 36: 1614 - 1624. PubMed
  38. Ippati S, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  39. Chan E, et al. 2016. Sci Rep. 6: 26119. PubMed
  40. Lee CYD et al. 2018. Neuron. 97(5):1032-1048 . PubMed
  41. Zhang Y, et al. 2022. Bioact Mater. 11:192. PubMed
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  47. Meilandt WJ, et al. 2020. J Neurosci. 40:1956. PubMed
  48. Casali BT, et al. 2018. J Neuroinflammation. 15:43. PubMed
  49. Actor-Engel HS, et al. 2021. Eneuro. Online ahead of print. PubMed
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  58. Ye T, et al. 2021. Commun Biol. 4:195. PubMed
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  60. Arber C, et al. 2020. Mol Psychiatry. 25:2919. PubMed
  61. Su Q, et al. 2021. Alzheimers Res Ther. 13:07. PubMed
  62. Porter KN, et al. 2020. Front Aging Neurosci. 12:92. PubMed
  63. Lai RH, et al. 2022. Aging Cell. 21:e13670. PubMed
  64. Peng D, et al. 2022. Theranostics. 12:3862. PubMed
  65. Li T, et al. 2016. Nat Commun. 7:12082. PubMed
  66. Soto-Mercado V, et al. 2020. PLoS One. 15:e0221669. PubMed
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RRID
AB_2728527 (BioLegend Cat. No. 803014) AB_2565328 (BioLegend Cat. No. 803015) AB_2565329 (BioLegend Cat. No. 803016) AB_2565327 (BioLegend Cat. No. 803017)

Antigen Details

Structure
Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.
Distribution

Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle.
Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus.

Function
The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
APP/β-Amyloid
Antigen References
  1. Kumar A,?et al.?2015. Pharmacol. Rep. 67(2):195.
  2. Sadigh-Eteghad S,?et al. 2015. Med. Princ. Pract. 24(1):1
  3. Hampel H,?et al.?2015.?Expert Rev. Neurother.?15(1):83.
  4. Puig KL,?et al.?2012. ?Exp. Gerontol. 48(7): 608.
  5. Selkoe DJ,?et al.?2016.?EMBO Mol. Med.?8(6):595.
  6. Walsh DM,?et al.??2007.?J. Neurochem. 101(5):1172.
Gene ID
351 View all products for this Gene ID
UniProt
View information about beta-Amyloid, 1-16 on UniProt.org

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