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首页 > 抗体蛋白 > 抗体
PE anti-human MICA/MICB Antibody
产品名称：
PE anti-human MICA/MICB Antibody
产品类别：
抗体
产品编号：
320906
产品应用：
320906
[价格]
规格 价格 库存
100tests ￥ 2844 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported (for the relevant formats) applications include: immunohistochemistry2,3,5 of acetone-fixed frozen sections and formalin-fixed paraffin-embedded tissue sections, immunoprecipitation7, and blocking2,3 of MIC mediated cytotoxicity. The Ultra-LEAF? Purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. Nos. 320919 & 320120).

Application References

(PubMed link indicates BioLegend citation)
  1. Groh V, et al. 1999. Science 279:1737.
  2. Groh V, et al. 1999. Proc. Natl. Acad. Sci. USA. 96:6879.
  3. Groh V, et al. 2001. Nature Immunol. 2:255.
  4. Li Z, et al. 2000. Immunogenetics 51:246.
  5. Park EJ, et al. 2003. J. Immunol. 171:4131.
  6. Jinushi M, et al. 2003. J. Immunol. 171:5423.
  7. Wu J, et al. 2003. J. Immunol. 170:4196.
Product Citations
  1. Ferrari de Andrade L, et al. 2020. Cancer Immunol Res. 0.867361111. PubMed
  2. Wang M, et al. 2022. Immun Inflamm Dis. 10:e626. PubMed
  3. Watanabe M, et al. 2014. Int Immunol. 26:597. PubMed
  4. Cordeau M, et al. 2016. PLoS One. 11:e0164401. PubMed
  5. Poznanski SM, et al. 2018. Cancer Immunol Res. 1.065277778. PubMed
  6. Godbersen C, et al. 2017. Mol Cancer Ther. 16:1335. PubMed
  7. Okita R, et al. 2021. Thorac Cancer. 12:775. PubMed
  8. Ritter C, et al. 2016. Sci Rep. 6:21678. PubMed
  9. Iwasa M, et al. 2019. Oncotarget. 10:1903. PubMed
  10. Hirano M, et al. 2021. J Exp Clin Cancer Res. 110:40. PubMed
  11. Tang S, et al. 2019. Biosci Rep. 39(7). PubMed
  12. Van der Meer JMR, et al. 2021. Oncoimmunology. 10:1981049. PubMed
  13. Kumashiro Y, et al. 2015. Small. 6: 681 - 687. PubMed
  14. Iraqi M, et al. 2020. Front Cell Infect Microbiol. 10:48. PubMed
  15. Suzuki D, et al. 2020. Stem Cell Reports. 14:49. PubMed
  16. Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed
  17. Siew Y, et al. 2015. Int Immunol. 27: 621 - 632. PubMed
RRID
AB_493193 (BioLegend Cat. No. 320906)

Antigen Details

Structure
65-75 kD glycoprotein, MHC class I-like transmembrane molecules that do not associate ?2-microglobulin, highly polymorphic
Distribution

Intestinal epithelium, epithelial tumors, endothelial cells, fibroblasts, INF-a-stimulated dendritic cells

Function
Activation of NK cells, subset of CD8+ α/? T cells and γ/δ T cells, suppression of T cell proliferation
Ligand/Receptor
NKG2D
Cell Type
Dendritic cells, Endothelial cells, Epithelial cells, Fibroblasts
Biology Area
Immunology, Innate Immunity
Molecular Family
MHC Antigens
Antigen References

1. Groh V, et al. 1996. Proc. Natl. Acad. Sci. USA. 93:12445.
2. Groh V, et al. 1999. Proc. Natl. Acad. Sci. USA. 96:6879.
3. Jinushi M, et al. 2003. J. Immunol. 170:1249.
4. Kriegeskorte AK, et al. 2005. Proc. Natl. Acad. Sci. USA. 102:11805.
5. Groh V, et al. 1999. Science 279:1737.

Gene ID
100507436 View all products for this Gene ID 4277 View all products for this Gene ID
UniProt
View information about MICA MICB on UniProt.org

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