Purified anti-human CD324 (E-Cadherin) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1212	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

T-47D cells

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
ICC, WB - Verified

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 ?g per million cells in 100 ?l volume.?For Western blotting, the suggested use of this reagent is 0.1 - 1.0 ?g per ml (dilution 1:5000 - 1:500). It is recommended that the reagent be titrated for optimal performance for each application.

Application References (PubMed link indicates BioLegend citation)

Armeanu S, et al. 1995. J. Cell Biol. 131:243.
Bühring HJ, et al. 1996. Leukemia 10:106.
Yauch RL, et al. 2005. Clin. Cancer Res. 11:8686. (WB)
Oeztuerk-Winder F, et al. 2012. EMBO J. 31:3431. (FC) PubMed
Ardehali R, et al. 2013. PNAS. 110:3405. PubMed
Rasanen K, et al. 2013. Mol Cell Protecomics. 12:3778. PubMed
Chaudhury A, et al. 2014. Nucleic Acids Res. 42:86. PubMed
Milne P, et al. 2015. Blood. 125:470. PubMed

Product Citations

Valencia J, et al. 2011. J Immunol. 187:4129. PubMed
Tanaka HY, et al. 2020. Biomaterials. 251:120077. PubMed
Wagner J et al. 2019. Cell. 177(5):1330-1345 . PubMed
Zhuang J, et al. 2019. Adv Sci (Weinh). 6:1901462. PubMed
Kumar M, et al. 2020. Oncotarget. 11:1603. PubMed
Bouchard G, et al. 2022. Cancer Res. 82:648. PubMed

RRID

AB_756063 (BioLegend Cat. No. 324101) AB_756064 (BioLegend Cat. No. 324102)

Antigen Details

Structure: Member of the cadherin superfamily. Calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of 4 extracellular cadherin repeats and a highly conserved cytoplasmic tail region. Predicted molecular weight approximately 100 kD.
Distribution: Widely expressed in epithelial cells in the colon, uterus, liver, keratinocytes, brain, heart, muscle, kidney, and pancreas, as well as erythroid cells
Function: Cell adhesion molecule involved in development, bacterial pathogenesis, and tumor invasion. The ectodomain of CD324 mediates bacterial adhesion to mammalian cell, while the cytoplasmic domain is required for internalization.
Interaction: Interacts with a variety of proteins including erbin, ezrin, caspase-3, caspase 8, EGF receptor, β-catenin, presenilin 1, casein kinase II, and others
Ligand/Receptor: α_Eβ₇ integrin
Modification: Phosphorylated on multiple residues (S857, S866, S870, S872), proteolytically cleaved at reside D769 by caspase-3.
Cell Type: Embryonic Stem Cells, Epithelial cells, Erythrocytes
Biology Area: Cell Biology, Immunology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Overduin M, et al. 1995. Science 267:386.
2. Boggon TJ, et al. 2002. Science 296:1303.
3. Berx G, et al. 1995. EMBO J. 14:6107.
4. Perl AK, et al. 1998. Nature 392:190.
Gene ID: 999 View all products for this Gene ID
UniProt: View information about CD324 on UniProt.org

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