FITC anti-human CD324 (E-Cadherin) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1272	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

T-47D cells

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Blue Laser (488 nm)

Application References (PubMed link indicates BioLegend citation)

Armeanu S, et al. 1995. J. Cell Biol. 131:243.
Bühring HJ, et al. 1996. Leukemia 10:106.
Yauch RL, et al. 2005. Clin. Cancer Res. 11:8686. (WB)
Oeztuerk-Winder F, et al. 2012. EMBO J. 31:3431. (FC) PubMed
Ardehali R, et al. 2013. PNAS. 110:3405. PubMed
Rasanen K, et al. 2013. Mol Cell Protecomics. 12:3778. PubMed
Chaudhury A, et al. 2014. Nucleic Acids Res. 42:86. PubMed
Milne P, et al. 2015. Blood. 125:470. PubMed

Product Citations

Theodoraki MN, et al. 2018. Oncoscience. 5:75. PubMed
Zhao Q, et al. 2018. Cancer Res. 78:2370. PubMed
Lin JR et al. 2018. eLife. 7 pii: e31657. PubMed
Chandrasekaran S, et al. 2011. Biomaterials. 32:7159. PubMed
Aboulkheyr Es H, et al. 2021. J Cell Physiol. 236:3918. PubMed
Es HA, et al. 2021. Cancers (Basel). 13:. PubMed
Wu Y, et al. 2014. Cancer Lett. 342:82. PubMed

RRID

AB_756065 (BioLegend Cat. No. 324103) AB_756066 (BioLegend Cat. No. 324104)

Antigen Details

Structure: Member of the cadherin superfamily. Calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of 4 extracellular cadherin repeats and a highly conserved cytoplasmic tail region. Predicted molecular weight approximately 100 kD.
Distribution: Widely expressed in epithelial cells in the colon, uterus, liver, keratinocytes, brain, heart, muscle, kidney, and pancreas, as well as erythroid cells
Function: Cell adhesion molecule involved in development, bacterial pathogenesis, and tumor invasion. The ectodomain of CD324 mediates bacterial adhesion to mammalian cell, while the cytoplasmic domain is required for internalization.
Interaction: Interacts with a variety of proteins including erbin, ezrin, caspase-3, caspase 8, EGF receptor, β-catenin, presenilin 1, casein kinase II, and others
Ligand/Receptor: α_Eβ₇ integrin
Modification: Phosphorylated on multiple residues (S857, S866, S870, S872), proteolytically cleaved at reside D769 by caspase-3.
Cell Type: Embryonic Stem Cells, Epithelial cells, Erythrocytes
Biology Area: Cell Biology, Immunology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Overduin M, et al. 1995. Science 267:386.
2. Boggon TJ, et al. 2002. Science 296:1303.
3. Berx G, et al. 1995. EMBO J. 14:6107.
4. Perl AK, et al. 1998. Nature 392:190.
Gene ID: 999 View all products for this Gene ID
UniProt: View information about CD324 on UniProt.org

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