Purified anti-human CD357 (GITR) Antibody
- 产品名称：
- Purified anti-human CD357 (GITR) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 311602
- 产品应用：
- 311602
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 311606).
- Application References
(PubMed link indicates BioLegend citation) -
- Kwon B, et al. 1999. J. Biol. Chem. 274:6056.
- Zhou Z, et al. 2008. Proc Natl Acad Sci USA . 105:5465 PubMed
- Product Citations
-
- Zhou Z, et al. 2008. Proc Natl Acad Sci U S A. 105:5465. PubMed
- Gide TN, et al. 2019. Cancer Cell. 35:238. PubMed
- Glaczynska M, et al. 2021. In Vivo. 35:283. PubMed
- Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
- RRID
- AB_314885 (BioLegend Cat. No. 311602)
- Structure
- TNFR superfamily, 234-amino acid type I transmembrane protein, 25 kD
- Distribution
-
Activated lymphocytes
- Function
- Interacts with TRAF's 1-3, but not TRAF 5 or 6, mediates NF-κB activation through the TRAF2/NIK pathway
- Ligand/Receptor
- GITRL
- Cell Type
- Lymphocytes, Tregs
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Kwon B, et al. 1999. J. Biol. Chem. 274:6056.
- Gene ID
- 8784 View all products for this Gene ID
- UniProt
- View information about CD357 on UniProt.org
