Biotin anti-mouse CD39 Antibody
- 产品名称：
- Biotin anti-mouse CD39 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 135703
- 产品应用：
- 135703
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified recombinant mCD39-Ig, mCD39-expressing pcDNA3.1 plasmid, and B cells (CD39+)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
WB, ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Zhou Q, et al. 2009. Am J. Transplant. 9(10):2303
- Product Citations
-
- Browning LM, et al. 2020. Cell Rep. 33:108219. PubMed
- RRID
- AB_2099921 (BioLegend Cat. No. 135703) AB_2099920 (BioLegend Cat. No. 135704)
- Structure
- A member of ectonucleoside triphosphate dihydrolases (E-NTPDases), an ectoenzyme that degrades ATP to AMP.
- Distribution
-
CD39 is expressed on B cells, dendritic cells, and a subset of T cells
- Function
- CD39 is involved in suppression of inflammation and control of platelet activation. Coordinated expression of CD39/CD73 on Tregs and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops.
- Cell Type
- B cells, Dendritic cells, T cells, Tregs
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Borsellino G et al. 2007. Blood 110(4):1225
2. Deaglio S et al. 2007. J. Exp. Med. 204(6):1257
3. Bynoe MS. et al. 2008. Trends Immunol. 29(3):99
4. Ndhlovu LC. et al. Eur. J. Immunol. 2009 Oct 28. [Epub ahead of print]
- Gene ID
- 12495 View all products for this Gene ID
- UniProt
- View information about CD39 on UniProt.org
