首页 > 抗体蛋白 > 抗体
Purified anti-mouse GITR Ligand Antibody
产品名称:
Purified anti-mouse GITR Ligand Antibody
产品类别:
抗体
产品编号:
147402
产品应用:
147402
[价格]
规格 价格 库存
100µg ¥ 3180 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additonal reported applications (for relevant formats of thes clone) include: inhibition of GITR-GITRL mediated T cell proliferation and reversing Treg-mediated suppression1.

The following patents apply to clone 5F1: U.S. Patent Serial No. 7,618,632 and Japan Patent Serial No. 4638876.

Application References

(PubMed link indicates BioLegend citation)
  1. Stephens GL, et al. 2004. J. Immunol. 173:5008. (Block)
RRID
AB_2563295 (BioLegend Cat. No. 147402)

Antigen Details

Structure
TNF superfamily member
Distribution
B cells, macrophages, dendritic cells, endothelial cells
Function
Binds GITR receptor to costimulate T cell activation, proliferation, and cytokine production; inhibits the suppressive activities of CD4+CD25+ Tregs
Cell Type
B cells, Macrophages, Dendritic cells, Endothelial cells, Tregs
Biology Area
Immunology
Antigen References

1. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059.
2. Kim JD, et al. 2003. Genes Immun. 4:564.
3. Yu KY, et al. 2003. Biochem. Biophys. Res. Commun. 310:433.
4. Shin HH, et al. 2002. Cytokine 19:187.

Gene ID
240873 View all products for this Gene ID
UniProt
View information about GITR Ligand on UniProt.org

联系我们

TEL:021-34661275  点击拨打热线