Purified anti-Tapasin (Tapbp) Antibody
- 产品名称：
- Purified anti-Tapasin (Tapbp) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 696702
- 产品应用：
- 696702
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- Partial mouse tapasin peptide (11-34 a.a.)
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone does not cross-reacts with human (in-house tested). This antibody recognizes a non-specific band over 100 kD in some tested cell lysates.
- Product Citations
-
- Deng J, et al. 2021. Nat Cancer. 2:503. PubMed
- RRID
- AB_2687096 (BioLegend Cat. No. 696702)
- Structure
- 465 amino acids with a predicted molecular weight of 50 kD. An isoform with predicted MW of 47kD was reported.
- Distribution
-
Endoplasmic reticulum membrane
- Function
- Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide.
- Interaction
- Interacts with TAP1 and is thus a subunit of the TAP complex. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, ERp57 and TAP.
- Cell Type
- Embryonic Stem Cells
- Biology Area
- Cell Biology, Immunology, Stem Cells, Ubiquitin/Protein Degradation
- Molecular Family
- MHC Antigens
- Antigen References
-
- ?Neefjes J, et al. 2011. Nat. Rev. Immunol. 11:823-36.
- Dong G, et al. 2009. Immunity. 30:21.
- Fisette O, et al. 2016. Sci. Rep. 6:19085.
- Dick TP, et al. 2002. Immunity. 16: 87.
- Ortmann B, et al. 1997. Science. 277: 1306.
- Thuring C, et al. 2015. Br. J. Cancer. 113:952.??
- Han LY, et al. 2008. Clin. Cancer Res. 14: 3372.
- Seliger B, et al. 2010. Cancer Immunol. Immunother. 59: 529.
- Gene ID
- 21356 View all products for this Gene ID
- UniProt
- View information about Tapasin on UniProt.org
