Purified anti-FMRP Antibody (Previously Covance ca-上海雅吉生物科技有限公司

规格	价格	库存
25µL	￥ 1272	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

This monoclonal antibody was raised against a recombinant protein isolated from baculovirus expressing mouse FMRP.

Formulation

Phosphate-buffered solution.

Preparation

The antibody was purified by affinity chromatography.

Concentration

1 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.

Application

WB - Quality tested
ICC, IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 ?g/ml is suggested.?For immunocytochemistry, a concentration range of 5.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is effective in immunoblotting (WB), immunohistochemistry?on formalin-fixed paraffin-embedded tissue (IHC-P) and immunocytochemistry (ICC).

The epitope for 5C2 lies between amino acids 347-353 of FMRP. This clone does not cross react with FXR1 or FXR2.

Application References (PubMed link indicates BioLegend citation)

Gholizadeh S, et al. 2014. Neuropsychopharmacology. 39:3100.

Product Citations

Kalinowska M, et al. 2022. Mol Autism. 13:29. PubMed
Raj N, et al. 2021. Cell Reports. 35(2):108991. PubMed
Graef JD, et al. 2020. Eur J Neurosci. 51:2143. PubMed
Liu XS, et al. 2018. Cell. 172:979. PubMed

RRID

AB_2750045 (BioLegend Cat. No. 834702) AB_2564993 (BioLegend Cat. No. 834701)

Antigen Details

Structure: Expected MW: 68-80 kD (smaller truncations of FMRP seen at lower molecular weights)
Biology Area: Cell Biology, Neuroscience, Synaptic Biology, Transcription Factors
Molecular Family: Postsynaptic proteins, Presynaptic proteins
Gene ID: 2332 View all products for this Gene ID
UniProt: View information about FMRP on UniProt.org

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