Purified anti-human MERTK Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3312	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

MERTK extracellular domain/Fc fusion.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References (PubMed link indicates BioLegend citation)

Rogers AE, et al. 2012. Oncogene 31:4171.

Product Citations

Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed
Bassil R, et al. 2021. Nat Commun. 12:5220. PubMed

RRID

AB_2565898 (BioLegend Cat. No. 367602)

Antigen Details

Structure: Transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain.
Distribution: Macrophages, monocytes, and dendritic cells.
Function: TLR regulation, efferocytosis, phagocytosis regulation, cell survival, and macrophage migration.
Interaction: GRB2, PLCG2, and TNK2.
Ligand/Receptor: LGALS3, TUB, TULP1, and GAS6.
Cell Type: Dendritic cells, Macrophages, Monocytes
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Motility/Cytoskeleton/Structure, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family: Protein Kinases/Phosphatase, Toll Like Receptors
Antigen References: 1. Schlegel J, et al. 2013. J. Clin. Invest. 123:2257.
2. Chen J, et al. 1997. Oncogene 14:2033.
3. Yefimova MG, et al. 2013. Autophagy 9:653.
4. Zhang W, et al. 2013. J. Med. Chem. 56:9693.
5. Lee YJ, et al. 2012. J. Leuko. Biol. 91:921.
6. Krause S, et al. 2015. Blood 125:820.
7. Tang Y, et al. 2015. PLoS One 10:e0117787.
Gene ID: 10461 View all products for this Gene ID
UniProt: View information about MERTK on UniProt.org

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