APC/Fire™ 750 anti-human MERTK Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1908	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

MERTK extracellular domain/Fc fusion.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with APC/Fire? 750 under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC -?Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

* APC/Fire? 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.

Excitation Laser

Red Laser (633 nm)

Application References (PubMed link indicates BioLegend citation)

Rogers AE, et al. 2012. Oncogene 31:4171.

RRID

AB_2721482 (BioLegend Cat. No. 367613) AB_2721483 (BioLegend Cat. No. 367614)

Antigen Details

Structure: Transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain.
Distribution: Macrophages, monocytes, and dendritic cells.
Function: TLR regulation, efferocytosis, phagocytosis regulation, cell survival, and macrophage migration.
Interaction: GRB2, PLCG2, and TNK2.
Ligand/Receptor: LGALS3, TUB, TULP1, and GAS6.
Cell Type: Dendritic cells, Macrophages, Monocytes
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Motility/Cytoskeleton/Structure, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family: Protein Kinases/Phosphatase, Toll Like Receptors
Antigen References: 1. Schlegel J, et al. 2013. J. Clin. Invest. 123:2257.
2. Chen J, et al. 1997. Oncogene 14:2033.
3. Yefimova MG, et al. 2013. Autophagy 9:653.
4. Zhang W, et al. 2013. J. Med. Chem. 56:9693.
5. Lee YJ, et al. 2012. J. Leuko. Biol. 91:921.
6. Krause S, et al. 2015. Blood 125:820.
7. Tang Y, et al. 2015. PLoS One 10:e0117787.
Gene ID: 10461 View all products for this Gene ID
UniProt: View information about MERTK on UniProt.org

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