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首页 > 抗体蛋白 > 抗体
PE anti-mouse Siglec H Antibody
产品名称：
PE anti-mouse Siglec H Antibody
产品类别：
抗体
产品编号：
129605
产品应用：
129605
[价格]
规格 价格 库存
25µg ￥ 1836 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Siglec-H-Fc recombinant fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Blasius AL, et al. 2006. J. Immunol. 177:3260.
Product Citations
  1. Miller CM, et al. 2020. J Virol. 94:00:00. PubMed
  2. Furuta Y, et al. 2017. PLoS One. 12(2):e0172509. PubMed
  3. Mogilenko DA, et al. 2020. Immunity. 54(1):99-115.e12. PubMed
  4. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  5. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  6. Leylek R, et al. 2019. Cell Rep. 29:3736. PubMed
  7. Brown CC, et al. 2020. Cell. 179(4):846-863.e24.. PubMed
  8. Bradley KC, et al. 2019. Cell Rep. 28:245. PubMed
  9. Trefzer A, et al. 2021. Cell Reports. 34(6):108748. PubMed
  10. Li C, et al. 2021. Cell Metabolism. 33(8):1610-1623.e5. PubMed
  11. Shiozawa S, et al. 2022. iScience. 25:103537. PubMed
  12. Youshani AS, et al. 2019. J Neuroinflammation. 16:25. PubMed
  13. Rappe JCF, et al. 2021. J Exp Med. 218:. PubMed
  14. Dyer DP et al. 2019. Immunity. 50(2):378-389 . PubMed
  15. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  16. Uematsu T, et al. 2015. Sci Rep. 5: 17577. PubMed
RRID
AB_1227763 (BioLegend Cat. No. 129605) AB_2189147 (BioLegend Cat. No. 129606)

Antigen Details

Structure
Sialic acid-binding immunoglobulin-like lectins
Distribution

Siglec-H is expressed exclusively on natural interferon-producing cells (IPCs), also called plasmacytoid dendritic cells in spleen, blood and lymph nodes. The IPCs are characterized by a complex phenotype (CD11c+, Ly-6C+, B220+, CD11b-, CD8+/-).

Function
Siglec-H associates with adaptor protein DAP12 for cell signaling, which reduces type 1 IFN response of IPC to CpG.
Ligand/Receptor
Sialic acid
Cell Type
Dendritic cells
Biology Area
Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Siglec Molecules
Antigen References

1. Blasius AL, et al. 2006. Blood 107:2474.
2. Zhang J, et al. 2006. Blood 107:3600.
3. Blasius AL, et al. 2007. J. Exp. Med. 204:2561.

Gene ID
233274 View all products for this Gene ID
UniProt
View information about Siglec H on UniProt.org

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