PE anti-human HIF1α Antibody
- 产品名称：
- PE anti-human HIF1α Antibody
- 产品类别：
- 抗体
- 产品编号：
- 359703
- 产品应用：
- 359703
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1836 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant HIF1α
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Product Citations
-
- Sohrabi Y, et al. 2020. Front Immunol. 11:353. PubMed
- Surace L, et al. 2021. Nat Immunol. 22:1367. PubMed
- Marn Franco JL, et al. 2020. Cell Reports. 33(13):108547. PubMed
- Sohrabi Y, et al. 2019. Front Immunol. 9:3155. PubMed
- Prado-Garcia H, et al. 2020. Front Oncol. 10:807. PubMed
- Victorino F, et al. 2021. eLife. 0.416666666666667. PubMed
- Venet F, et al. 2017. J Immunol. 10.4049/jimmunol.1700127. PubMed
- RRID
- AB_2562422 (BioLegend Cat. No. 359703) AB_2562423 (BioLegend Cat. No. 359704)
- Structure
- 92.6 kD, contains one basic helix-loop-helix structure (bHLH), one PAS associated C - terminal (PAC) domain and two PER-ARNT-SIM (PAS) domains
- Distribution
- Under normoxic conditions detected in the cytoplasm; oxygen starvation causes nuclear translocation
- Function
- Master regulator of hypoxia in the adaptive immune response; under low oxygen conditions, induces expression of multiple genes such as VEGF, erythropoietin, and other genes that aid in adaptation to low oxygen concentrations
- Interaction
- Heterodimer binds 5'-[AG]CGTG-3' sequence of DNA in the hypoxia response element of target genes; interacts with COPS5, EP300, CITED2
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
1. Wang GL and Semenza GL.?1993. Proc. Natl. Acad. Sci. 90:4304.
2. Wang GL and Semenza GL.?1993. J. Biol. Chem. 268:21513.
3. Wang GL and Semenza GL.?1995. J. Biol. Chem. 270:1230.
4. Galbraith MD, et al. 2013. Cell. 153:1327.
- Gene ID
- 3091 View all products for this Gene ID
- UniProt
- View information about HIF1a on UniProt.org
