APC anti-mouse CD319 Antibody
- 产品名称：
- APC anti-mouse CD319 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 152003
- 产品应用：
- 152003
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- CD319-Fc fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- RRID
- AB_2632674 (BioLegend Cat. No. 152003) AB_2632675 (BioLegend Cat. No. 152004)
- Structure
- Extracellular domain with one Ig like V-set domain and one Ig like C2-set domain, and an cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs.
- Distribution
-
Spleen, lymph node, bone marrow, testis, thymus; NK cells, B cells, and subsets of T cells.
- Function
- Activates immune responses in NK cells when coupled with SAP-family adaptors (SAP, EAT-2, ERT).
- Interaction
- Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN, and SAP-family adaptors (SAP, EAT-2, ERT).
- Cell Type
- B cells, NK cells, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Li Y, et al. 2013. PLoS One 8(9):e76681.
2. Dongre P, et al. 2013. Mol. Immunol. 54:254-63.
3. Tovar V, et al. 2002. Immunogenetics 54:394.
4. Dong Z, et al. 2009. Nat. Immunol. 10:973.
- Gene ID
- 75345 View all products for this Gene ID
- UniProt
- View information about CD319 on UniProt.org
