Purified anti-human CD334 (FGFR4) Antibody
- 产品名称：
- Purified anti-human CD334 (FGFR4) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 324302
- 产品应用：
- 324302
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- NIH-3T3 cells transfected with full-length human FGFR4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
ICC?- Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per 106 cells in 100 ?L?volume or 100 ?L?of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Bussolati B, et al. 2012. Am J Physiol Renal Physiol. 302:116. PubMed.
- Product Citations
-
- Bussolati B, et al. 2012. Am J Physiol Renal Physiol. 302:F116. PubMed
- RRID
- AB_756088 (BioLegend Cat. No. 324302)
- Structure
- Member of the fibroblast growth factor receptor family. Cell surface tyrosine kinase containing three immunoglobulin-like domains. Predicted molecular weight approximately 88 kD.
- Distribution
-
Widely expressed in many tissues including the intestine, muscle, heart, cornea, retina, and pancreas; highest expression in lung and kidney
- Function
- Ligand binding induces mitogenesis and differentiation; over-expressed in gynecological tumors suggesting a possible role for this receptor in breast and ovarian tumorigenesis. Unique alleles (Arg388) in FGFR4 have been associated with cancer progression
- Interaction
- STAT1, STAT3
- Ligand/Receptor
- Binds acidic fibroblast growth factors (FGF8, GFG1, FGF19, FGF6, and FGF2)
- Cell Type
- Neural Stem Cells
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells, Synaptic Biology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
1. Holtrich U, et al. 1991. Proc. Natl. Acad. Sci. USA 88:10411.
2. Partanen J, et al. 1991. EMBO J. 10:1347.
3. Bange J, et al. 2002. Cancer Res. 62:840.
4. Vainikka S, et al. 1992. EMBO J. 11:4273.
- Gene ID
- 2264 View all products for this Gene ID
- UniProt
- View information about CD334 on UniProt.org
