Purified anti-human CD32B/C Antibody
- 产品名称：
- Purified anti-human CD32B/C Antibody
- 产品类别：
- 抗体
- 产品编号：
- 398402
- 产品应用：
- 398402
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Extracellular domain of human CD32B
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
As the extracellular region of CD32B and CD32C are identical, this Ab recognizes both isoforms. Does not crossreact with CD32A.
- Application References
(PubMed link indicates BioLegend citation) -
- Su K, et al. 2007. J Immunol. 178:3272
- RRID
- AB_2814383 (BioLegend Cat. No. 398402)
- Structure
- Type I transmembrane protein, 40 kDa, member of the Ig superfamily
- Distribution
-
B cells, subsets of monocytes,macrophages and granulocytes, platelets, mast cells.
- Function
- Negatively regulates cell activation, proliferation, endocytosis, phagocytosis, and degranulation
- Ligand/Receptor
- Fc region of complex or aggregated immunoglobulins gamma
- Cell Type
- B cells, Dendritic cells, Granulocytes, Monocytes, Platelets
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Fc Receptors
- Antigen References
-
- Bruhns P,?et al.?2009.?Blood.?113: 3716.
- Bewarder N,?et al.?1996.?Mol Cell Biol.?16: 4735.
- Descours B,?et al. 2017.?Nature?543: 564.
- Tomiyama Y,?et al. 1992.?Blood.?80: 2261.
- Indik Z,?et al. 1991.?J Clin Invest.?88: 1766.
- Ramsland PA,?et al. 2011.?J Immunol.?187: 3208.
- Hogarth PM and Pietersz GA. 2012.?Nat Rev Drug Discov. 11: 311.
- Bournazos S,?et al. 2009.?J Immunol. 182: 8026.
- Maxwell KF,?et al. 1999.?Nat Struct Biol.?6: 437.
- Sandilands GP,?et al. 1997.?Immunology.?91: 204.
- Ghazizadeh S,?et al. 1994.?J Biol Chem.?269: 8878.
- Gillis C,?et al. 2014.?Front Immunol.?5: 254.
- Gene ID
- 2213 View all products for this Gene ID 9103 View all products for this Gene ID
- UniProt
- View information about CD32B CD32C on UniProt.org
