APC anti-mouse TIGIT (Vstm3) Antibody
- 产品名称：
- APC anti-mouse TIGIT (Vstm3) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 156105
- 产品应用：
- 156105
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- Mouse TIGIT Tetramers
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?L?volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
It was reported that this clone can block the interaction between mouse TIGIT and CD155.
- Application References
(PubMed link indicates BioLegend citation) -
- Joller N,?et al.?2011.?J. Immunol.?186:1338.
- RRID
- AB_2750514 (BioLegend Cat. No. 156105) AB_2750515 (BioLegend Cat. No. 156106)
- Structure
- Type I transmembrane protein, 26 kD, member of the CD28 family. Contains 1 Ig-like domain and 1 cytoplasmic ITIM motif.
- Distribution
-
Activated T cells, follicular T helper cells, NK, memory T cells, Tregs.
- Function
- Negative regulator of T cell activation and proliferation. Induction of tolerogenic dendritic cells.
- Ligand/Receptor
- CD155 (PVR) and CD112 (PVRL2).
- Cell Type
- Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- Adhesion Molecules, Immune Checkpoint Receptors
- Antigen References
-
- Levin SD,?et al.?2011.?Eur. J. Immunol.?41:902.
- Yu X,?et al.?2009.?Nat. Immunol.?10:48.
- Stanietsky N,?et al.?2009.?Proc.?Natl. Acad. Sci.?USA 106:17858
- Gene ID
- 100043314 View all products for this Gene ID
- UniProt
- View information about TIGIT on UniProt.org
