Purified anti-Siglec-11 Antibody
- 产品名称：
- Purified anti-Siglec-11 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 681702
- 产品应用：
- 681702
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Siglec-11 fused to Fc region of human IgG.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Angata T, et al. 2002. J. Biol. Chem. 277:24466.
- RRID
- AB_2566496 (BioLegend Cat. No. 681702)
- Structure
- 698 amino acids, predicted molecular weight of 66 kD. Apparent molecular weight is 100-130 kD due to N-glycosylation.
- Distribution
-
Plasma membrane.
- Function
- Adhesion molecule that mediates sialic-acid dependent binding to cells. The cytosolic domain of Siglec-11 is phosphorylated at tyrosine residue(s) upon pervanadate treatment of cells and then it recruits the protein-tyroisine phosphatases SHP-1 and SHP-2. Such interaction induces inhibitory cellular signals in immune response.
- Interaction
- Interacts with PTPN6/SHP-1 and PTPN11/SHIP-2 upon phosphorylation.
- Ligand/Receptor
- α-2,8-linked sialic acid trimers.
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, Siglec Molecules
- Antigen References
-
1. Angata T, et al. 2002. J. Biol. Chem. 277:24466.
2. Hayakawa T, et al. 2005. Science 309:1693.
3. Kopatz J, et al. 2014. Glycobiology 9:794.
4. Wang Y, et al. 2010. J. Neurosci. 30:3482.
5. Linnartz B, et al. 2010. Int. J. Alzheimers Dis. 2010.
- Gene ID
- 114132 View all products for this Gene ID
- UniProt
- View information about Siglec-11 on UniProt.org
