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PE anti-human CD137 (4-1BB) Antibody
产品名称：
PE anti-human CD137 (4-1BB) Antibody
产品类别：
抗体
产品编号：
309803
产品应用：
309803
[价格]
规格 价格 库存
25tests ￥ 1416 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ectodomain of recombinant human 4-1BB fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,4, inhibition of cytokine production2,3, and ELISA. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 309804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by Streptavidin-PE (Cat. No. 405204)).

Application References

(PubMed link indicates BioLegend citation)
  1. Garni-Wagner B, et al. 1996. Cell. Immunol. 169:91. (IP)
  2. Salih HR, et al. 2000. J. Immunol. 165:2903. (FA)
  3. Kienzle G, et al. 2000. Int. Immunol. 12:73. (FA)
  4. Langstein J, et al. 1998. J. Immunol. 160:2488. (IP)
Product Citations
  1. Liu T, et al. 2021. Gut. 70:1965. PubMed
  2. Yamaguchi S, et al. 2021. Eur J Immunol. 51:2306. PubMed
  3. Shitaoka K, et al. 2018. Cancer Immunol Res. 6:378. PubMed
  4. Arce Vargas F et al. 2018. Cancer cell. 33(4):649-663 . PubMed
  5. Lamichhane R, et al. 2020. Eur J Immunol. 50:178. PubMed
  6. Goncharov MM, et al. 2022. Elife. 11:. PubMed
  7. Shin JJ, et al. 2022. J Clin Immunol. :. PubMed
  8. Jutz S, et al. 2016. J Immunol Methods. 430:10-20. PubMed
  9. Rajamanickam V, et al. 2021. Cancer Immunol Res. 9:602. PubMed
  10. Jung JH, et al. 2021. Nat Commun. 12:4043. PubMed
  11. Pavlicek D, et al. 2017. Immun Ageing. 14:22. PubMed
  12. Gordon-Alonso M,et al. 2017. Nat. Commun. 10.1038/s41467-017-00925-6. PubMed
  13. Elias G, et al. 2022. Elife. 11:. PubMed
  14. Prado-Garcia H, et al. 2017. Cancer Immunol Immunother. 10.1007/s00262-017-1979-x. PubMed
  15. Correnti CE, et al. 2020. Nat Struct Mol Biol. 27:342. PubMed
  16. Gao R, et al. 2018. Oncoimmunology. 7:e1438108. PubMed
  17. Tian L, et al. 2022. Clin Cancer Res. 28:201. PubMed
  18. Senger K, et al. 2022. Curr Protoc. 2:e538. PubMed
  19. Lamichhane R et al. 2019. Cell Rep. 28(12):3061-3076 . PubMed
RRID
AB_314782 (BioLegend Cat. No. 309803) AB_314783 (BioLegend Cat. No. 309804)

Antigen Details

Structure
TNFR superfamily, type I transmembrane protein, 30 kD
Distribution

Activated T cells

Function
T cell costimulation
Ligand/Receptor
4-1BB ligand
Cell Type
T cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Gruss H, et al. 1995. Blood 85:3378.
2. Sica G, et al. 2000. Adv. Exp. Med. Biol. 465:355.
3. Alderson M, et al. 1994. Eur. J. Immunol. 24:2219.
4. Schwarz H, et al. 1996. Blood 87:2839.

Gene ID
3604 View all products for this Gene ID
UniProt
View information about CD137 on UniProt.org

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