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Brilliant Violet 421™ anti-human CD137 (4-1B
产品名称：
Brilliant Violet 421™ anti-human CD137 (4-1B
产品类别：
抗体
产品编号：
309819
产品应用：
309819
[价格]
规格 价格 库存
25tests ￥ 2280 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ectodomain of recombinant human 4-1BB fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1,4, inhibition of cytokine production2,3, and ELISA. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 309804) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by Streptavidin-PE (Cat. No. 405204)).

Application References

(PubMed link indicates BioLegend citation)
  1. Garni-Wagner B, et al. 1996. Cell. Immunol. 169:91. (IP)
  2. Salih HR, et al. 2000. J. Immunol. 165:2903. (FA)
  3. Kienzle G, et al. 2000. Int. Immunol. 12:73. (FA)
  4. Langstein J, et al. 1998. J. Immunol. 160:2488. (IP)
Product Citations
  1. Sulejmani O, et al. 2021. Cancers (Basel). 13:. PubMed
  2. Balachandran H, et al. 2022. Cell Rep. 38:110345. PubMed
  3. Iwahori K, et al. 2019. Sci Rep. 2.205555556. PubMed
  4. Wenthe J, et al. 2021. Cancer Immunology Immunotherapy. . PubMed
  5. Freeman ZT, et al. 2020. J Clin Invest. 130:1405. PubMed
  6. Lamichhane R, et al. 2020. Eur J Immunol. 50:178. PubMed
  7. Harris MJ, et al. 2021. Mol Syst Biol. 17:e10091. PubMed
  8. Hu W, et al. 2021. Vaccines (Basel). 9:. PubMed
  9. Vanshylla K, et al. 2022. Cell Host Microbe. 30:69. PubMed
  10. Smith AS, et al. 2022. J Immunother Cancer. 10:. PubMed
  11. Andersch L, et al. 2019. BMC Cancer. 19:895. PubMed
  12. Vitanza NA, et al. 2021. Nature Medicine. :. PubMed
  13. Buggert M, et al. 2020. Cell. 183(7):1946-1961.e15. PubMed
  14. Sekine T, et al. 2020. Cell. 183:158. PubMed
  15. Georg P, et al. 2022. Cell. 185:493. PubMed
  16. Genoyer E, et al. 2019. J Virol. 93:e01579-18. PubMed
RRID
AB_10895902 (BioLegend Cat. No. 309819) AB_2563830 (BioLegend Cat. No. 309820)

Antigen Details

Structure
TNFR superfamily, type I transmembrane protein, 30 kD
Distribution

Activated T cells

Function
T cell costimulation
Ligand/Receptor
4-1BB ligand
Cell Type
T cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Gruss H, et al. 1995. Blood 85:3378.
2. Sica G, et al. 2000. Adv. Exp. Med. Biol. 465:355.
3. Alderson M, et al. 1994. Eur. J. Immunol. 24:2219.
4. Schwarz H, et al. 1996. Blood 87:2839.

Gene ID
3604 View all products for this Gene ID
UniProt
View information about CD137 on UniProt.org

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