Purified anti-CD324 (E-Cadherin) Antibody
- 产品名称：
- Purified anti-CD324 (E-Cadherin) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 866701
- 产品应用：
- 866701
- Verified Reactivity
- Human, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Lower MW bands detected in WB are cleaved C terminal fragments.
Cleavage of E-cadherin usually occurs in tumor development and cleaved E-cadherin fragments of ~29-38 kD often possess distinct oncogenic properties.
- Application References
(PubMed link indicates BioLegend citation) -
- David, J.M. and Rajasekaran, A.K. 2012. Cancer Res. 72(12): 2917–2923.
- RRID
- AB_2814610 (BioLegend Cat. No. 866701) AB_2814611 (BioLegend Cat. No. 866702)
- Structure
- Human CD324 (E-cadherin) is a 882 amino acid protein with a predicted molecular mass of 97 kD and observed molecular mass of ~120 kD.
- Distribution
-
Tissue distribution: Non-neural epithelial tissues and forebrain germinal zones
Cellular distribution: Golgi, plasma membrane, endosome, and cell
- Function
- CD324 (E-cadherin) is involved in cell adhesion.
- Interaction
- Interacts with catenin family members
- Cell Type
- Embryonic Stem Cells, Epithelial cells, Neural Stem Cells
- Biology Area
- Cell Adhesion, Cell Biology, Immuno-Oncology, Immunology, Neuroscience, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
- Lewis-Tuffin LJ, et al. 2010. PLoS One. 5(10):e13665.
- Karpowicz P, et al. 2009. J Neurosci. 29(12):3885-96.
- Gene ID
- 999 View all products for this Gene ID
- UniProt
- View information about CD324 on UniProt.org
