Purified anti-Tau, 1-100 Antibody (Previously Cova
- 产品名称：
- Purified anti-Tau, 1-100 Antibody (Previously Cova
- 产品类别：
- 抗体
- 产品编号：
- 816603
- 产品应用：
- 816603
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Application
-
WB -?Quality tested
IHC-P -?Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. For immunohistochemistry, a concentration range of 1.0 - 5.0 ?g/ml is suggested.?It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is reactive to amino acid residues 1-100 of human Tau. The epitope lies within amino acids 6-18. This clone is specific for all six isoforms of human tau protein.
This antibody clone has been reported for use on IHC of 4% PFA-fixed free floating sections5.
This antibody is exclusively provided by BioLegend.
- Product Citations
-
- Gu J, et al. 2020. J Biol Chem. 295:13812. PubMed
- Wu R, et al. 2021. Front Mol Neurosci. 14:631833. PubMed
- Li L, et al. 2021. Acta Neuropathol Commun. 9:28. PubMed
- RRID
- AB_2715839 (BioLegend Cat. No. 816603) AB_2564800 (BioLegend Cat. No. 816601)
- Structure
- Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
- Distribution
-
Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: cytoskeleton, nucleus, plasma membrane and cytosol.
- Function
- Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- Interaction
- Tau interacts with Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, Alpha-synuclein
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Tau
- Antigen References
-
- Augustinack JC,?et al.?2002.?Acta Neuropath. 103(1):26-35.
- Seubert P,?et al.?1995.?J Biol Chem.?270(32):18917-22.
- Dong Y,?et al. 2012.?PLoS One. 7(6):e39386.
- Simic G, et al. 2016. Biomolecules. 6(1):6.
- Dai CL, et al. 2017. Alzheimers Res Ther. 9(1):1. (IHC, WB) [PubMed]
- Baazaoui N, et al. 2017. Alzheimers Res Ther. 9:45. ( WB) [PubMed]
- Dai CL, et al. 2015. J neural Transm (Vienna). 122:607.
- Gene ID
- 4137 View all products for this Gene ID
- UniProt
- View information about Tau, 1-100 on UniProt.org
