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Purified anti-human CD307d (FcRL4) Antibody
产品名称:
Purified anti-human CD307d (FcRL4) Antibody
产品类别:
抗体
产品编号:
340202
产品应用:
340202
[价格]
规格 价格 库存
100µg ¥ 3876 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
P815 cells transfected with FcRL4
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (with relevant formats) include: immunoprecipitation and blocking. mAb 413D12 is able to block the binding of FcRL4 to aggregated IgA, IgG3, and IgG4.

Application References

(PubMed link indicates BioLegend citation)
  1. Sohn HW, et al. 2011. Blood. 118:6332. PubMed
  2. Wilson TJ, et al. 2012. J. Immunol. 188:4741. (Block)
Product Citations
  1. Jourdan M, et al. 2017. PLoS One. 12(6):e0179793. PubMed
RRID
AB_2231789 (BioLegend Cat. No. 340202)

Antigen Details

Structure
57 kD, Fc receptor like, four Ig like domains
Distribution

Subset of memory B cells, some multiple myeloma and non-Hodgkins lymphoma

Interaction
Tyrosine phophorylated FcRL4 interacts with SHP-1, SHP-2 to inhibit the B cell receptor
Bioactivity
B-cell receptor inhibition
Cell Type
B cells
Biology Area
Immunology
Molecular Family
CD Molecules, Fc Receptors
Antigen References

1. Moir S, et al. 2008. J. Exp. Med. 205:1797.
2. Ehrhardt GRA, et al. 2003. P. Natl. Acad. Sci. USA 100:13489.
3. Ehrhardt GRA, et al. 2005. J. Exp. Med. 202:783.
4. Polson AG, et al. 2006. J. Int. Immunol. 18:1363.

Gene ID
83417 View all products for this Gene ID
UniProt
View information about CD307d on UniProt.org

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