APC anti-human CD307d (FcRL4) Antibody
- 产品名称：
- APC anti-human CD307d (FcRL4) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 340205
- 产品应用：
- 340205
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 1788 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- P815 cells transfected with FcRL4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Additional reported applications (with relevant formats) include: immunoprecipitation and blocking. mAb 413D12 is able to block the binding of FcRL4 to aggregated IgA, IgG3, and IgG4.
- Application References
(PubMed link indicates BioLegend citation) -
- Sohn HW, et al. 2011. Blood. 118:6332. PubMed
- Wilson TJ, et al. 2012. J. Immunol. 188:4741. (Block)
- Product Citations
-
- Magri G et al. 2017. Immunity. 47(1):118-134 . PubMed
- Fu Y, et al. 2021. Cell Reports. 36(2):109344. PubMed
- RRID
- AB_10710013 (BioLegend Cat. No. 340205) AB_10709439 (BioLegend Cat. No. 340206)
- Structure
- 57 kD, Fc receptor like, four Ig like domains
- Distribution
-
Subset of memory B cells, some multiple myeloma and non-Hodgkins lymphoma
- Interaction
- Tyrosine phophorylated FcRL4 interacts with SHP-1, SHP-2 to inhibit the B cell receptor
- Bioactivity
- B-cell receptor inhibition
- Cell Type
- B cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Fc Receptors
- Antigen References
-
1. Moir S, et al. 2008. J. Exp. Med. 205:1797.
2. Ehrhardt GRA, et al. 2003. P. Natl. Acad. Sci. USA 100:13489.
3. Ehrhardt GRA, et al. 2005. J. Exp. Med. 202:783.
4. Polson AG, et al. 2006. J. Int. Immunol. 18:1363.
- Gene ID
- 83417 View all products for this Gene ID
- UniProt
- View information about CD307d on UniProt.org
