Purified anti-human HB-EGF Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 4620	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Human HB-EGF, extracellular domain (recombinant)

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Concentration

0.5 mg/mL

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
ICC, WB, IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25??g per million cells in 100 ?L volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References (PubMed link indicates BioLegend citation)

Hamaoka M, et al. 2010. J Biochem. 148:55.

RRID

AB_2927862 (BioLegend Cat. No. 383702)

Antigen Details

Distribution

Monocytes, macrophages, T cells, neutrophils, eosinophils, myeloid leukemia blasts, myeloma cells, vascular smooth muscle cells, endothelial cells, and normal or neoplastic epithelial cells

Function

HB-EGF is associated with proliferation and differentiation of stromal cells, apoptosis, and morphogenesis. It participates in inflammation, wound healing, atherosclerotic plaque progression, and cardiac valvulogenesis. TNF-α and IL-1β induces HB-EGF in endothelial cells.

Interaction

Fibroblast, smooth muscle cells, monocytes/macrophages, endothelial cells, astrocytes, keratinocytes, normal and neoplastic epithelial cells

Ligand/Receptor

EGFR (ErbB1) and ErbB4; also binds to heparan-sulphate proteoglycans

Cell Type

Epithelial cells, Macrophages, T cells

Biology Area

Angiogenesis, Cancer Biomarkers

Molecular Family

Growth Factors

Antigen References

Higashiyama S, et al. 1991. Science. 251:936.
Hirata M, et al. 2001. Biochem. Biophys. Res. Commun. 283:915.
Jackson LF, et al. 2003. EMBO J. 22:2704.
Nishi E, et al. 2006. J. Biol. Chem. 281:31164.
Yotsumoto F, et al. 2008. Biochem. Biophys. Res. Commun. 365:555.
Ota I, et al. 2013. Oncol Rep. 30:1593.

Gene ID

1839 View all products for this Gene ID

UniProt

View information about HB-EGF on UniProt.org

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