Purified anti-human CCL13 (MCP-4) Antibody
- 产品名称：
- Purified anti-human CCL13 (MCP-4) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 537602
- 产品应用：
- 537602
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ELISA Capture - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of 0.4 - 3 ?g/mL is recommended. To obtain a linear standard curve, serial dilutions of CCL13 (MCP4) recombinant protein ranging from 3.9 to 250 pg/mL is recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The pure 3G4 (Cat. No. 537602) antibody is useful as the capture antibody in a sandwich ELISA assay, paired with biotinylated 8C12 (Cat. No. 537704) and Lyophilized CCL13 (MCP4) (Cat. No. 587509).?
- RRID
- AB_2783351 (BioLegend Cat. No. 537602)
- Structure
- Chemokine
- Distribution
-
Epithelial cells, endothelial cells, fibroblasts, chondrocytes, macrophages
- Function
- CCL13 chemoattract monocytes, eosinophils, CD4, and CD8 T cells. CCL13 induces histamine release from IL-3-primed peripheral blood basophils. IFN-γ induces CCL13 in bronchial epithelial cell lines, endothelial cells, and chondrocytes, and a synergistic effect is obtained with INF-γ and TNF-α or IL-1 in chondrocytes. CCL13 is processed and inactivated by MMP-12.
- Interaction
- Monocytes, dendritic cells, basophils, eosinophils, T cells
- Ligand/Receptor
- CCR2, CCR3, and CCR5
- Cell Type
- Endothelial cells, Epithelial cells, Fibroblasts, Macrophages
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Uguccioni M, et al.?1996. J. Exp. Med. 183:2379.
- Godiska R, et al.?1997. J. Leuko. Biol. 61:353.
- Kalayci O, et al.?2004. J.?Asthma 41:27.
- Iwamoto T, et al.?2007. FEBS J. 274:4904.
- Mendez-Enriquez E, et al.?2008. Clin. Exp. Immunol. 152:354.
- Hintzen C, et al.?2009. Arthritis Rheum. 60:1932.
- Dean RA, et al.?2008. Blood 112:3455.
- Breland UM, et al.?2010. Cardiovasc. Res. 86:265.
- Gene ID
- 6357 View all products for this Gene ID
- UniProt
- View information about CCL13 on UniProt.org
