Purified anti-SSRP1 Antibody
- 产品名称：
- Purified anti-SSRP1 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 609802
- 产品应用：
- 609802
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant (partial)
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified
IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 ?g per 5 ml antibody dilution buffer for each mini-gel. For immunocytochemistry, a concentration range of 2.5 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).
- Application References
(PubMed link indicates BioLegend citation) -
- Tan B C-M, et al. 2006. EMBO doi:10.1038/sj.emboj.7601271
- Product Citations
-
- Horiuchi S, et al. 2021. Sci Immunol. :eabm3131. PubMed
- RRID
- AB_2195751 (BioLegend Cat. No. 609802)
- Structure
- SSRP family, HMG box domain; 81 kD
- Distribution
-
Nuclear
- Function
- Interacts with nucleosomes and histone H2A/H2B dimers to promote nucleosome disassembly and allow transcription elongation, binds to dsDNA. Modified by cisplatin, may protect DNA from repair and block DNA replication
- Interaction
- Component of FACT ATP-dependent chromatin remodeling complex, Spt16/Cdc68 in FACT complex, H2A/H2B dimers
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, DNA Repair/Replication, Transcription Factors
- Antigen References
-
1. LeRoy G, et al. 1998. Science 282:1836.
2. Orphanides G, et al. 1998. Cell 92:105.
3. Orphanides G, et al. 1999. Nature 400:284.
- Gene ID
- 6749 View all products for this Gene ID
- UniProt
- View information about SSRP1 on UniProt.org
