Purified anti-Dynactin 1 (N-Terminus) Antibody
- 产品名称：
- Purified anti-Dynactin 1 (N-Terminus) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 867601
- 产品应用：
- 867601
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified recombinant Dynactin 1 protein fragments expressed in E.coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2814614 (BioLegend Cat. No. 867601) AB_2814615 (BioLegend Cat. No. 867602)
- Structure
- Dynactin 1 is a 1278 amino acid protein with two reported isoforms. A brain-specific isoform with predicted and observed molecular mass of ~135 kD, and a ubiquitously expressed isoform with predicted and observed molecular mass of ~150 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Cytoskeleton, cytosol, and nucleus
- Function
- Dynactin 1 recruits dynein to microtubules and facilitates retrograde transport of vesicles and organelles.
- Interaction
- Dynactin 1 forms homodimer and interacts with dynein.
- Biology Area
- Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance, Synaptic Biology
- Molecular Family
- Adaptor Proteins, Carrier Proteins, Cytoskeletal Proteins, Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Konno T, et al. 2017. Parkinsonism Relat Disord. 41:14.
- Houlden H, et al. 2012. Acta Neuropath. 124(3):325.
- Tanaka F, et al. 2011. Rinsho Shinkeigaku. 51(11):1189.
- Gene ID
- 1639 View all products for this Gene ID
- UniProt
- View information about Dynactin 1 on UniProt.org
