PE anti-AIM2 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1908	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant fragment, corresponding to amino acids 1-186 of human AIM2 with a GST tag.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

ICFC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by intracellular flow cytometry using our True-Nuclear? Transcription Factor Staining Protocol. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application Notes

Additional reported applications (for the relevant formats) include: Western blotting¹, immunofluorescence staining³ and immunoprecipitation².

NOTE: For flow cytometric staining with this clone, True-Nuclear? Transcription Factor Buffer Set (Cat. No. 424401) offers improved staining and is highly recommended.

Application References (PubMed link indicates BioLegend citation)

Pierini R, et al. 2012. Cell Death Differ. 19:1709. (WB)
Fernandez-Alnemri T, et al. 2009. Nature 7237:509. (IP)
Sagulenko V, et al. 2013. Cell Death Differ. 9:1149. (IF)

Product Citations

Svensson A, et al. 2017. PLoS One.. 10.1371/journal.pone.0183268. PubMed

RRID

AB_2566000 (BioLegend Cat. No. 652803) AB_2566001 (BioLegend Cat. No. 652804)

Antigen Details

Structure: 343 amino acids with predicted molecular weight of 39 kD.
Distribution: Cytosol.
Function: Tumor suppressor which may act by repressing NF-κ B transcriptional activity.
Biology Area: Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity
Antigen References: 1. DeYoung KL, et al. 1997. Oncogene 15:453.
2. Choubey D, et al. 2000. FEBS Lett. 474:38.
3. Chen IF, et al. 2006. Mol. Cancer Ther. 5:1.
4. Roberts TL, et al. 2009. Science 323:1057.
5. Jones JW, et al. 2010. Proc. Natl. Acad. Sci. USA 107:9771.
6. Fernandes-Alnemri T, et al. 2010. Nat. Immunol. 11:385.
7. Schroder K and Tschopp J. 2010. Cell 140:821.
8. Jin T, et al. 2012. Immunity 36:561.
Gene ID: 9447 View all products for this Gene ID
UniProt: View information about AIM2 on UniProt.org

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