Purified anti-β-Amyloid, 1-15 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1548	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

This antibody was raised against dityrosine cross-linked human Aβ1-40.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

IHC-F - Quality tested
Direct ELISA - Verified
IHC-P - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 1.0 - 5.0 ?g/ml is suggested.?For ELISA applications, a concentration range of 0.01 - 1.0 ?g/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include:?formalin-fixed paraffin-embedded immunohistochemical staining (IHC-P).

Application References (PubMed link indicates BioLegend citation)

Frost JL, et al. 2015. Neurobiol Aging. 36(12):3187 (IHC-P)
Lardenoije R, et al. 2018. Mol. Cell. Neurosci. 86:1-15. (IHC-P) PubMed

RRID

AB_2728567 (BioLegend Cat. No. 847501) AB_2728568 (BioLegend Cat. No. 847502)

Antigen Details

Structure

Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.

Distribution

Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle.

Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus.

Function

The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.

Interaction

Tau, Prion

Biology Area

Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

APP/β-Amyloid

Antigen References