Purified anti-Tau, 189-195 Antibody (Previously Co-上海雅吉生物科技有限公司

规格	价格	库存
25µL	￥ 1344	1

Product Details

Verified Reactivity

Human, Mouse, Rat

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

This monoclonal antibody was raised against full-length human tau.

Formulation

Phosphate-buffered solution (no preservatives or carrier proteins).

Preparation

The antibody was purified by affinity chromatography.

Concentration

1.0 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.

Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is effective in immunoblotting (WB).

BioLegend is the Exclusive Provider of this Antibody Product

Application References (PubMed link indicates BioLegend citation)

Michalski V, et.al.?Neurobiol Aging.?2015. 36(12):3131. (WB)?PubMed

Product Citations

Mammadova N, et al. 2017. Am J Pathol. 187:1459. PubMed

RRID

AB_2715844 (BioLegend Cat. No. 814302) AB_2564782 (BioLegend Cat. No. 814301)

Antigen Details

Structure: Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
Distribution: Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.
Function: Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Interaction: Tau interacts with: Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family: Tau
Antigen References: 1. Meredith JE Jr,?et al.?2013.?PLoS One. 8(10): e76523.?PubMed
2. Goodall CA,?et al.?2006.?J. Neurol. Neurosurg. Psychiatry?77(1): 89.?PubMed
3. Wang Y, Mandelkow E. 2016.?Nat. Rev. Neurosci. 17(1):5-21.?PubMed
Gene ID: 4137 View all products for this Gene ID
UniProt: View information about Tau 189-195 on UniProt.org

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