Ultra-LEAF™ Purified anti-mouse IL-25 (IL-17
- 产品名称：
- Ultra-LEAF™ Purified anti-mouse IL-25 (IL-17
- 产品类别：
- 抗体
- 产品编号：
- 514417
- 产品应用：
- 514417
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- IL-25
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is <0.01 EU/?g of the protein (<0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
ELISA - Quality tested
Neut - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Neutralization: The Ultra-LEAF? purified antibody (Endotoxin <0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for neutralization of mouse IL-25 bioactivity (Cat. No. 514417).
- Application References
(PubMed link indicates BioLegend citation) -
- Angkasekwinai P, et al. 2007. J. Exp Med. 204:1509.
- Product Citations
-
- Fu Y, et al. 2020. Mol Ther. 1214:28. PubMed
- RRID
- AB_2814443 (BioLegend Cat. No. 514417) AB_2814444 (BioLegend Cat. No. 514418)
- Structure
- Cytokine; 19 kD
- Bioactivity
- Induce proinflammatory responses, promote the expression of the prototypical Th2 genes
- Cell Sources
- Activated Th2 cells, bone marrow-derived mast cells, and alveolar macrophages
- Cell Targets
- IL-17RB mRNA transcripts are abundantly expressed in the kidney and liver and at lower levels in the testes, brain, small intestine, and other organs.
- Receptors
- IL-17BR (EVI27, IL17Rh1)
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. Fort MM, et al. 2001. Immunity 15:985.
2. Lee J, et al. 2001. J. Biol Chem. 276:1660.
3. Hurst SD, et al. 2002. J. Immunol. 169:443.
4. Kleinschel MA, et al. 2007. J. Exp. Med. 204:161.
- Gene ID
- 140806 View all products for this Gene ID
- UniProt
- View information about IL-25 on UniProt.org
