Purified anti-mouse CD40 Antibody
- 产品名称：
- Purified anti-mouse CD40 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 124601
- 产品应用：
- 124601
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD40 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IHC-F - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 124627 &124628) with a low?endotoxin limit?(Endotoxin < 0.01 EU/?g).
- Application References
(PubMed link indicates BioLegend citation) -
- Hasbold J, et al. 1994. Eur. J. Immunol. 24:1835.
- Bourgeois C, et al. 2002. Science 297:2060.
- Product Citations
-
- Wang W, et al. 2018. Cancer Cell. 34:757. PubMed
- Yamane M, et al. 2020. FASEB J. 34:10778. PubMed
- Song K, et al. 2017. Oncotarget. 8:38554. PubMed
- Diao J, et al. 2018. J Immunol. 201:1306. PubMed
- Bessell CA, et al. 2020. JCI Insight. 5:. PubMed
- RRID
- AB_1134239 (BioLegend Cat. No. 124601) AB_1134240 (BioLegend Cat. No. 124602)
- Structure
- 48 kD type I transmembrane glycoprotein, a member of the tumor necrosis factor receptor (TNFR) superfamily.
- Distribution
-
Expressed on B lymphocytes and other antigen-presenting cells, such as macrophages, follicular dendritic cells, etc.
- Function
- Regulates B cell growth and differentiation and Ig isotype switching. Interaction of CD40 with its ligand, CD154, on activated T cells is important for immune response.
- Ligand/Receptor
- CD154 on T cells
- Cell Type
- Antigen-presenting cells, B cells, Dendritic cells, Macrophages
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
-
1. Grewal IS, et al. 1998. Annu Rev Immunol 16:111.
- Gene ID
- 21939 View all products for this Gene ID
- UniProt
- View information about CD40 on UniProt.org
