PE/Cyanine7 anti-mouse CD40 Antibody
- 产品名称：
- PE/Cyanine7 anti-mouse CD40 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 124621
- 产品应用：
- 124621
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD40 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume.? It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 124627 &124628) with a low?endotoxin limit?(Endotoxin < 0.01 EU/?g).
- Additional Product Notes
- BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
- Application References
(PubMed link indicates BioLegend citation) -
- Hasbold J, et al. 1994. Eur. J. Immunol. 24:1835.
- Bourgeois C, et al. 2002. Science 297:2060.
- Product Citations
-
- Sun L, et al. 2021. Cancer Cell. :. PubMed
- Pierini S, et al. 2021. J Immunother Cancer. 9:. PubMed
- Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
- Findlay EG, et al. 2019. Oncoimmunology. 8:1608106. PubMed
- Marangoni F, et al. 2021. Cell. . PubMed
- Huang YL, et al. 2015. Nat Commun. 6: 8141. PubMed
- Ciecko AE, et al. 2019. Cell Rep. 29:3073. PubMed
- Wu G, et al. 2020. Br J Pharmacol. 177:5063. PubMed
- Wang H, et al. 2019. Nat Commun. 10:1898. PubMed
- Mehta AK, et al. 2021. Nat Cancer. 2:66. PubMed
- Fontinha D, et al. 2015. PLoS One. 10: 0142540. PubMed
- Zhang J, et al. 2018. Sci Rep. 8:2373. PubMed
- Kramer K, et al. 2017. ACS Omega. 0.240972222. PubMed
- Elayeb R, et al. 2016. Haematologica. 101: 209 - 218. PubMed
- Gomez S, et al. 2022. J Immunother Cancer. 10:. PubMed
- Lu X, et al. 2019. Circ Res. 125:1055. PubMed
- Moufarrij S, et al. 2020. Sci Rep. 10:3470. PubMed
- Wu Y, et al. 2015. J Immunol. 195: 2612-2623. PubMed
- Silva-Cayetano A, et al. 2020. Med. 2(3):243-262.e8. PubMed
- Zhang X, et al. 2021. Front Pharmacol. 12:706748. PubMed
- Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
- Wang Y, et al. 2020. Vaccines (Basel). 8:. PubMed
- Lal JC, et al. 2021. Breast Cancer Res. 23:83. PubMed
- Yang F, et al. 2021. Nat Commun. 12:3424. PubMed
- RRID
- AB_10933422 (BioLegend Cat. No. 124621) AB_10897812 (BioLegend Cat. No. 124622)
- Structure
- 48 kD type I transmembrane glycoprotein, a member of the tumor necrosis factor receptor (TNFR) superfamily.
- Distribution
-
Expressed on B lymphocytes and other antigen-presenting cells, such as macrophages, follicular dendritic cells, etc.
- Function
- Regulates B cell growth and differentiation and Ig isotype switching. Interaction of CD40 with its ligand, CD154, on activated T cells is important for immune response.
- Ligand/Receptor
- CD154 on T cells
- Cell Type
- Antigen-presenting cells, B cells, Dendritic cells, Macrophages
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
-
1. Grewal IS, et al. 1998. Annu Rev Immunol 16:111.
- Gene ID
- 21939 View all products for this Gene ID
- UniProt
- View information about CD40 on UniProt.org
