FITC anti-mouse CD40 Antibody
- 产品名称：
- FITC anti-mouse CD40 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 124607
- 产品应用：
- 124607
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD40 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
- Application Notes
For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 124627 &124628) with a low?endotoxin limit?(Endotoxin < 0.01 EU/?g).
- Application References
(PubMed link indicates BioLegend citation) -
- Hasbold J, et al. 1994. Eur. J. Immunol. 24:1835.
- Bourgeois C, et al. 2002. Science 297:2060.
- Product Citations
-
- Jaiswal AK, et al. 2020. Immunobiology. 225:151956. PubMed
- Xia S, et al. 2014. J Leukoc Biol. 95:733. PubMed
- Kim TJ, et al. 2019. Nat Commun. 10:3258. PubMed
- Takeda Y, et al. 2018. Innate Immun. 24:323. PubMed
- Clement M, et al. 2016. PLoS Pathog. 12:e1006050. PubMed
- Lin SY, et al. 2017. Autophagy. 14:778. PubMed
- Yl?sm?ki E, et al. 2021. J Immunother Cancer. 9:. PubMed
- Zhou Y, et al. 2020. Front Pharmacol. 10:1579. PubMed
- Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
- Kishore M et al. 2017. Immunity. 47(5):875-889 . PubMed
- Nikolos F, et al. 2022. Nat Commun. 13:1487. PubMed
- Ma W, et al. 2017. Cell Death & Disease. 10.1038/cddis.2017.47. PubMed
- Benhamron S, et al. 2012. PLoS One. 7:e35602. PubMed
- Kelly SH, et al. 2021. ACS Biomater Sci Eng. 7:1876. PubMed
- Nechama M, et al. 2018. Nat Commun. 9:1603. PubMed
- Shevtsova AS, et al. 2017. Front Microbiol. 1.8. PubMed
- Pantelidou C, et al. 2022. NPJ Breast Cancer. 8:102. PubMed
- Li H, et al. 2022. iScience. 25:104481. PubMed
- Hayashi K, et al. 2020. Nat Commun. 4.832638889. PubMed
- RRID
- AB_1134090 (BioLegend Cat. No. 124607) AB_1134096 (BioLegend Cat. No. 124608)
- Structure
- 48 kD type I transmembrane glycoprotein, a member of the tumor necrosis factor receptor (TNFR) superfamily.
- Distribution
-
Expressed on B lymphocytes and other antigen-presenting cells, such as macrophages, follicular dendritic cells, etc.
- Function
- Regulates B cell growth and differentiation and Ig isotype switching. Interaction of CD40 with its ligand, CD154, on activated T cells is important for immune response.
- Ligand/Receptor
- CD154 on T cells
- Cell Type
- Antigen-presenting cells, B cells, Dendritic cells, Macrophages
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
-
1. Grewal IS, et al. 1998. Annu Rev Immunol 16:111.
- Gene ID
- 21939 View all products for this Gene ID
- UniProt
- View information about CD40 on UniProt.org
