APC anti-mouse CD40 Antibody
- 产品名称：
- APC anti-mouse CD40 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 124611
- 产品应用：
- 124611
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CD40 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
For highly sensitive assays, we recommend Ultra-LEAF? purified antibody (Cat. No. 124627 &124628) with a low?endotoxin limit?(Endotoxin < 0.01 EU/?g).
- Application References
(PubMed link indicates BioLegend citation) -
- Hasbold J, et al. 1994. Eur. J. Immunol. 24:1835.
- Bourgeois C, et al. 2002. Science 297:2060.
- Product Citations
-
- Espinosa-Cueto P, et al. 2017. PLoS One.. 10.1371/journal.pone.0182126. PubMed
- Kiritsy MC, et al. 2021. Elife. 10:. PubMed
- Chakrabarti J, et al. 2018. Oncotarget. 9:37439. PubMed
- Zhao J, et al. 2019. Nat Commun. 10:899. PubMed
- Jiang C, et al. 2020. Cell Reports. 28(5):1307-1322.e8.. PubMed
- Polavaram NS, et al. 2021. Bone Res. 9:24. PubMed
- Russler-Germain EV, et al. 2021. Elife. 10:. PubMed
- Guo Y, et al. 2022. Nat Commun. 13:6534. PubMed
- Farkas A, et al. 2013. J Immunol. 190:3319. PubMed
- Guo S, et al. 2021. Sci Rep. 11:23745. PubMed
- Gong N, et al. 2020. Nat Nanotechnol. 1.35625. PubMed
- Morgado P, et al. 2011. Infect Immun. 79:4401. PubMed
- Wang Y, et al. 2021. Nat Commun. 12:4964. PubMed
- Grabinger T, et al. 2019. Front Microbiol. 10:1385. PubMed
- Nakazawa Y, et al. 2021. Elife. 10:. PubMed
- Ren S, et al. 2022. Int J Biol Sci. 18:166. PubMed
- Mino T, et al. 2019. Nucleic Acids Res. 47:8838. PubMed
- Yang F, et al. 2021. Nat Commun. 12:3424. PubMed
- RRID
- AB_1134081 (BioLegend Cat. No. 124611) AB_1134072 (BioLegend Cat. No. 124612)
- Structure
- 48 kD type I transmembrane glycoprotein, a member of the tumor necrosis factor receptor (TNFR) superfamily.
- Distribution
-
Expressed on B lymphocytes and other antigen-presenting cells, such as macrophages, follicular dendritic cells, etc.
- Function
- Regulates B cell growth and differentiation and Ig isotype switching. Interaction of CD40 with its ligand, CD154, on activated T cells is important for immune response.
- Ligand/Receptor
- CD154 on T cells
- Cell Type
- Antigen-presenting cells, B cells, Dendritic cells, Macrophages
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules
- Antigen References
-
1. Grewal IS, et al. 1998. Annu Rev Immunol 16:111.
- Gene ID
- 21939 View all products for this Gene ID
- UniProt
- View information about CD40 on UniProt.org
